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Peptide record

TPDB27762

Neurotoxin Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB27762
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia pep-lab ToxinPred 3.0
standard
No
A 31-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, pep-lab, and other sources, with an available 3D structural model.
Sequence
YCQKWMWTCDEERKCCEGLVCRLWCKRIINM
Physicochemical Analysis
C169H264N48O44S8
AHFPS
C
3928.73
8.02
6
4
11
+2
3.78
-0.377
59.68
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
18365
467.45
10
Residue Composition
number
0
A
3
R
1
N
1
D
6
C
3
E
1
Q
1
G
0
H
2
I
2
L
3
K
2
M
0
F
0
P
0
S
1
T
3
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 1 C: 6 E: 3 Q: 1 G: 1 H: 0 I: 2 L: 2 K: 3 M: 2 F: 0 P: 0 S: 0 T: 1 W: 3 Y: 1 V: 1
Chemical Descriptors
31
C169H264N48O44S8
3928.73
8.02
+2
3.78
-0.377
Evidence Records 2 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks mammalian Kv4.2/KCND2 and Kv4.3/KCND3 (By similarity). Blocks mechanosensitive ion channels in rat astrocytes, without having effect on whole-cell voltage-sensitive currents (By similarity). {ECO:0000250|UniProtKB:P61231}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Grammostola rosea (Chilean rose tarantula) (Grammostola spatulata)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks mammalian Kv4.2/KCND2 and Kv4.3/KCND3 (By similarity). Blocks mechanosensitive ion channels in rat astrocytes, without having effect on whole-cell voltage-sensitive currents (By similarity)..
Kappa-theraphotoxin-Gr2a (Kappa-TRTX-Gr2a) (Toxin GsMTx-2) (MTx2)
spider
Neurotoxin 30 (phrixotoxin) family
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:12082099}.
Evidence 2 Activity

Activity

Neurotoxin
FUNCTION: Potent and specific blocker of Kv4.2/KCND2 (IC(50)=34 nM) and Kv4.3/KCND3 (IC(50)=71 nM) potassium channels (PubMed:10051143). Acts by altering the gating properties of these channels (PubMed:10051143). {ECO:0000269|PubMed:10051143}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Paraphysa scrofa (Chilean copper tarantula) (Phrixotrichus auratus)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Potent and specific blocker of Kv4.2/KCND2 (IC(50)=34 nM) and Kv4.3/KCND3 (IC(50)=71 nM) potassium channels (PubMed:10051143). Acts by altering the gating properties of these channels (PubMed:10051143)..
Kappa-theraphotoxin-Ps1b (Kappa-TRTX-Ps1b) (PaTX2) (Phrixotoxin-2)
spider
Neurotoxin 30 (phrixotoxin) family
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:10051143}.
Additional Detail Fields 7 fields
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin Amidation
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Neurotoxin 30 (phrixotoxin) family
Kappa-theraphotoxin-Gr2a (Kappa-TRTX-Gr2a) (Toxin GsMTx-2) (MTx2) Kappa-theraphotoxin-Ps1b (Kappa-TRTX-Ps1b) (PaTX2) (Phrixotoxin-2)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:12082099}. TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:10051143}.
spider