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Peptide record

TPDB27761

Neurotoxin Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB27761
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 31-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
TVCNLRRCQLSCRSLGLLGKCIGVKCECVKH
Physicochemical Analysis
C141H251N47O39S6
ADMFPWY
C
3421.20
8.92
7
1
9
+5
5.47
0.281
103.55
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
375
10.96
11
Residue Composition
number
0
A
3
R
1
N
0
D
6
C
1
E
1
Q
3
G
1
H
1
I
5
L
3
K
0
M
0
F
0
P
2
S
1
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 6 E: 1 Q: 1 G: 3 H: 1 I: 1 L: 5 K: 3 M: 0 F: 0 P: 0 S: 2 T: 1 W: 0 Y: 0 V: 3
Chemical Descriptors
31
C141H251N47O39S6
3421.20
8.92
+5
5.47
0.281
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocker for the small conductance calcium-activated potassium channels (PubMed:11527975, PubMed:8385026, PubMed:8457543). Shows similar affinities for KCa2.2/KCNN2 (Kd=22 nM) and KCa2.3/KCNN3 (Kd=25 nM) (PubMed:11527975). {ECO:0000269|PubMed:11527975, ECO:0000269|PubMed:8385026, ECO:0000269|PubMed:8457543}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Androctonus mauritanicus mauritanicus (Scorpion)
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Blocker for the small conductance calcium-activated potassium channels (PubMed:11527975, PubMed:8385026, PubMed:8457543). Shows similar affinities for KCa2.2/KCNN2 (Kd=22 nM) and KCa2.3/KCNN3 (Kd=25 nM) (PubMed:11527975)..
Potassium channel toxin alpha-KTx 5.2 (AmPO5) (P05) (PO5) (Leiurotoxin I-like toxin P05)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 05 subfamily
Evidence at protein level
3D-structure Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:8385026}.
Additional Detail Fields 7 fields
3D-structure Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 05 subfamily
Potassium channel toxin alpha-KTx 5.2 (AmPO5) (P05) (PO5) (Leiurotoxin I-like toxin P05)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:8385026}.
scorpion