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Peptide record

TPDB27758

Neurotoxin Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB27758
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 31-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
AFCNLRRCELSCRSLGLLGKCIGEECKCVPY
Physicochemical Analysis
C146H243N43O42S6
DQHMTW
C
3465.16
8.02
5
3
10
+2
4.91
0.203
88.06
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1865
53.82
10
Residue Composition
number
1
A
3
R
1
N
0
D
6
C
3
E
0
Q
3
G
0
H
1
I
5
L
2
K
0
M
1
F
1
P
2
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 3 N: 1 D: 0 C: 6 E: 3 Q: 0 G: 3 H: 0 I: 1 L: 5 K: 2 M: 0 F: 1 P: 1 S: 2 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
31
C146H243N43O42S6
3465.16
8.02
+2
4.91
0.203
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks small conductance calcium-activated potassium channels (PubMed:12239213). Shows activity on KCa2.2/KCNN2 (IC(50)=0.0243 nM), KCa2.3/KCNN3 (IC(50)=1.7 nM), and KCa2.1/KCNN1 (IC(50)=42 nM) (PubMed:12239213). Induces cell death when tested on human T lymphoblastic leukemia Jurkat E6.1 and human breast cancer MDA-MB-231 cell lines which constituvely express KCa2.2/KCNN2, but not on human peripheral blood lymphocytes (which do not express KCa2.2/KCNN2) (PubMed:24821061). {ECO:0000269|PubMed:12239213}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Hottentotta tamulus (Eastern Indian scorpion) (Mesobuthus tamulus)
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Blocks small conductance calcium-activated potassium channels (PubMed:12239213). Shows activity on KCa2.2/KCNN2 (IC(50)=0.0243 nM), KCa2.3/KCNN3 (IC(50)=1.7 nM), and KCa2.1/KCNN1 (IC(50)=42 nM) (PubMed:12239213).
Potassium channel toxin alpha-KTx 5.4 (Tamapin)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 05 subfamily
Evidence at protein level
3D-structure Amidation Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:12239213}.
Additional Detail Fields 7 fields
3D-structure Amidation Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 05 subfamily
Potassium channel toxin alpha-KTx 5.4 (Tamapin)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:12239213}.
scorpion