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Peptide record

TPDB27757

Neurotoxin Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB27757
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 31-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
AFCNLRMCQLSCRSLGLLGKCIGDKCECVKH
Physicochemical Analysis
C142H242N44O40S7
PTWY
C
3430.17
8.31
6
2
10
+3
4.08
0.274
88.06
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
375
10.93
10
Residue Composition
number
1
A
2
R
1
N
1
D
6
C
1
E
1
Q
3
G
1
H
1
I
5
L
3
K
1
M
1
F
0
P
2
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 2 N: 1 D: 1 C: 6 E: 1 Q: 1 G: 3 H: 1 I: 1 L: 5 K: 3 M: 1 F: 1 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
31
C142H242N44O40S7
3430.17
8.31
+3
4.08
0.274
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocker for the small conductance calcium-activated potassium channels (PubMed:11527975, PubMed:2307683, PubMed:2839478). Shows the best affinity for KCa2.2/KCNN2 (Kd=0.2 nM), followed by KCa2.3/KCNN3 (Kd=1.1 nM) and KCa2.1/KCNN1 (Kd=325 nM) (PubMed:11527975). {ECO:0000269|PubMed:11527975, ECO:0000269|PubMed:2307683, ECO:0000269|PubMed:2839478}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Leiurus hebraeus (Hebrew deathstalker scorpion) (Leiurus quinquestriatus hebraeus)
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Blocker for the small conductance calcium-activated potassium channels (PubMed:11527975, PubMed:2307683, PubMed:2839478). Shows the best affinity for KCa2.2/KCNN2 (Kd=0.2 nM), followed by KCa2.3/KCNN3 (Kd=1.1 nM) and KCa2.1/KCNN1 (Kd=325 nM) (PubMed:11527975)..
Potassium channel toxin alpha-KTx 5.1 (Leiurotoxin I) (LeTx I) (Lei-I) (Leiurotoxin-1) (Scyllatoxin) (ScyTx)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 05 subfamily
Evidence at protein level
3D-structure Amidation Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:2839478}.
Additional Detail Fields 7 fields
3D-structure Amidation Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 05 subfamily
Potassium channel toxin alpha-KTx 5.1 (Leiurotoxin I) (LeTx I) (Lei-I) (Leiurotoxin-1) (Scyllatoxin) (ScyTx)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:2839478}.
scorpion