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Peptide record

TPDB27755

Neurotoxin Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB27755
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 31-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
AACYSSDCRVKCVAMGFSSGKCINSKCKCYK
Physicochemical Analysis
C138H226N40O42S7
EQHLPTW
C
3341.98
8.86
6
1
10
+5
2.72
-0.013
40.97
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
3355
100.39
14
Residue Composition
number
3
A
1
R
1
N
1
D
6
C
0
E
0
Q
2
G
0
H
1
I
0
L
5
K
1
M
1
F
0
P
5
S
0
T
0
W
2
Y
2
V
Amino Acid Distribution
A: 3 R: 1 N: 1 D: 1 C: 6 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 0 K: 5 M: 1 F: 1 P: 0 S: 5 T: 0 W: 0 Y: 2 V: 2
Chemical Descriptors
31
C138H226N40O42S7
3341.98
8.86
+5
2.72
-0.013
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Selective inhibitor of high conductance calcium-activated potassium channels KCa1.1/KCNMA1. May be insect specific. {ECO:0000269|PubMed:15178692, ECO:0000269|Ref.1}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Olivierus martensii (Manchurian scorpion) (Mesobuthus martensii)
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Selective inhibitor of high conductance calcium-activated potassium channels KCa1.1/KCNMA1. May be insect specific..
Potassium channel toxin alpha-KTx 19.1 (BmK37) (Neurotoxin BmBKTx1)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 19 subfamily
Evidence at protein level
3D-structure Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|Ref.1}.
Additional Detail Fields 7 fields
3D-structure Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 19 subfamily
Potassium channel toxin alpha-KTx 19.1 (BmK37) (Neurotoxin BmBKTx1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|Ref.1}.
scorpion