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Peptide record

TPDB27753

Neurotoxin Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB27753
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 30-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
SCSGRDSRCPPVCCMGLMCSRGKCVSIYGE
Physicochemical Analysis
C125H210N40O41S8
ANQHFTW
C
3185.77
8.02
4
2
7
+2
4.69
0.033
45.33
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
1865
58.54
12
Residue Composition
number
0
A
3
R
0
N
1
D
6
C
1
E
0
Q
4
G
0
H
1
I
1
L
1
K
2
M
0
F
2
P
5
S
0
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 1 C: 6 E: 1 Q: 0 G: 4 H: 0 I: 1 L: 1 K: 1 M: 2 F: 0 P: 2 S: 5 T: 0 W: 0 Y: 1 V: 2
Chemical Descriptors
30
C125H210N40O41S8
3185.77
8.02
+2
4.69
0.033
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: By structural similarity with conotoxin GS, may inhibit the sodium channel (Nav). No effect was observed upon intracranial injections into mice and intraperitoneal injections into goldfish (25 ug).

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus tulipa (Fish-hunting cone snail) (Tulip cone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
By structural similarity with conotoxin GS, may inhibit the sodium channel (Nav). No effect was observed upon intracranial injections into mice and intraperitoneal injections into goldfish (25 ug).
Conotoxin TVIIA
cone snail
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:10903496}.
Additional Detail Fields 6 fields
3D-structure Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Conotoxin TVIIA
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:10903496}.
cone snail