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Peptide record

TPDB27751

Neurotoxin Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB27751
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 30-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GCCGPYPNAACHPCGCKVGRPPYCDRPSGG
Physicochemical Analysis
C124H188N40O37S6
EQILMFTW
CGP
3023.46
8.02
4
1
5
+2
4.52
-0.523
16.33
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3355
110.97
10
Residue Composition
number
2
A
2
R
1
N
1
D
6
C
0
E
0
Q
6
G
1
H
0
I
0
L
1
K
0
M
0
F
6
P
1
S
0
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 2 R: 2 N: 1 D: 1 C: 6 E: 0 Q: 0 G: 6 H: 1 I: 0 L: 0 K: 1 M: 0 F: 0 P: 6 S: 1 T: 0 W: 0 Y: 2 V: 1
Chemical Descriptors
30
C124H188N40O37S6
3023.46
8.02
+2
4.52
-0.523
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin binds with high affinity to both fetal (alpha-1-beta-1-epsilon-delta (CHRNA1-CHRNB1-CHRND-CHRNE) subunits) and adult (alpha-1/beta-1/gamma/delta subunits) mammalian muscle nicotinic acetylcholine receptors (nAChR). {ECO:0000269|PubMed:9278406}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus ermineus (Agate cone) (Chelyconus ermineus)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin binds with high affinity to both fetal (alpha-1-beta-1-epsilon-delta (CHRNA1-CHRNB1-CHRND-CHRNE) subunits) and adult (alpha-1/beta-1/gamma/delta subunits) mammalian muscle nicotinic acetylcholine receptors (nAChR)..
Alpha-conotoxin EIVA
cone snail
Conotoxin A superfamily
Evidence at protein level
3D-structure Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:9278406}.
Additional Detail Fields 7 fields
3D-structure Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin EIVA
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:9278406}.
cone snail