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Peptide record

TPDB27748

Neurotoxin Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB27748
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 30-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
DDCGKLFSGCDTNADCCEGYVCRLWCKLDW
Physicochemical Analysis
C144H212N38O47S6
QHIMP
C
3419.85
3.93
3
6
9
-3
2.69
-0.247
52.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
12865
376.19
10
Residue Composition
number
1
A
1
R
1
N
5
D
6
C
1
E
0
Q
3
G
0
H
0
I
3
L
2
K
0
M
1
F
0
P
1
S
1
T
2
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 5 C: 6 E: 1 Q: 0 G: 3 H: 0 I: 0 L: 3 K: 2 M: 0 F: 1 P: 0 S: 1 T: 1 W: 2 Y: 1 V: 1
Chemical Descriptors
30
C144H212N38O47S6
3419.85
3.93
-3
2.69
-0.247
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibitor of voltage-gated potassium channels of the Kv4/KCND family. Inhibition of Kv4.3/KCND3 and Kv4.2/KCND2 is strongly voltage-dependent, while inhibition of Kv4.1/KCND1 shows less voltage-dependence. Its binding site may be near the potassium channel voltage sensor. Also blocks calcium channels. {ECO:0000269|PubMed:15733564, ECO:0000269|PubMed:9058605, ECO:0000269|Ref.2}.

Target

voltage-gated potassium channel (Kv) voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Heteropoda venatoria (Brown huntsman spider) (Aranea venatoria)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Inhibitor of voltage-gated potassium channels of the Kv4/KCND family. Inhibition of Kv4.3/KCND3 and Kv4.2/KCND2 is strongly voltage-dependent, while inhibition of Kv4.1/KCND1 shows less voltage-dependence.
Kappa-sparatoxin-Hv1b (Kappa-SPRTX-Hv1b) (Heteropodatoxin-2) (HpTX2) (Toxin KJ6)
spider
Neurotoxin 10 (Hwtx-1) family, 19 (HpTX2) subfamily
Evidence at protein level
3D-structure Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
3D-structure Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 19 (HpTX2) subfamily
Kappa-sparatoxin-Hv1b (Kappa-SPRTX-Hv1b) (Heteropodatoxin-2) (HpTX2) (Toxin KJ6)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider