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Peptide record

TPDB27747

Neurotoxin Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB27747
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 30-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
APWLVPSQITTCCGYNPGTMCPSCMCTNTC
Physicochemical Analysis
C131H204N34O42S8
RDEHKF
C
3183.74
4.94
0
0
8
-0
-1.46
0.270
39.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
7365
231.33
17
Residue Composition
number
1
A
0
R
2
N
0
D
6
C
0
E
1
Q
2
G
0
H
1
I
1
L
0
K
2
M
0
F
4
P
2
S
5
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 2 D: 0 C: 6 E: 0 Q: 1 G: 2 H: 0 I: 1 L: 1 K: 0 M: 2 F: 0 P: 4 S: 2 T: 5 W: 1 Y: 1 V: 1
Chemical Descriptors
30
C131H204N34O42S8
3183.74
4.94
-0
-1.46
0.270
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: May specifically activate neuronal voltage-gated sodium channels (Nav) at the resting membrane potential. Causes a marked contraction and extension of the caudal and dorsal fins in fish and noticeable spontaneous contractions of isolated frog neuromuscular preparations. {ECO:0000269|PubMed:10510177}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus consors (Singed cone)
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
May specifically activate neuronal voltage-gated sodium channels (Nav) at the resting membrane potential. Causes a marked contraction and extension of the caudal and dorsal fins in fish and noticeable spontaneous contractions of isolated frog neuromuscular preparations..
Conotoxin CcTx (Excitotoxin CcTx)
cone snail
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Glycoprotein Hydroxylation Ion channel impairing toxin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000269|PubMed:10510177}.
Additional Detail Fields 6 fields
3D-structure Direct protein sequencing Disulfide bond Glycoprotein Hydroxylation Ion channel impairing toxin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Conotoxin CcTx (Excitotoxin CcTx)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000269|PubMed:10510177}.
cone snail