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Peptide record

TPDB27746

Neurotoxin Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB27746
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia pep-lab ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, pep-lab, and other sources, with an available 3D structural model.
Sequence
YCQKWMWTCDSARKCCEGLVCRLWCKKII
Physicochemical Analysis
C156H245N43O38S7
NHFP
C
3555.35
8.58
6
2
11
+4
-0.31
-0.052
67.24
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
18365
516.55
10
Residue Composition
number
1
A
2
R
0
N
1
D
6
C
1
E
1
Q
1
G
0
H
2
I
2
L
4
K
1
M
0
F
0
P
1
S
1
T
3
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 1 C: 6 E: 1 Q: 1 G: 1 H: 0 I: 2 L: 2 K: 4 M: 1 F: 0 P: 0 S: 1 T: 1 W: 3 Y: 1 V: 1
Chemical Descriptors
29
C156H245N43O38S7
3555.35
8.58
+4
-0.31
-0.052
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potent and specific blocker of Kv4.2/KCND2 (IC(50)=5 nM) and Kv4.3/KCND3 (IC(50)=28 nM) potassium channels (PubMed:10051143). Acts by altering the gating properties of these channels (PubMed:10051143). Also shows moderate inhibition on human voltage-gated sodium channel Nav1.7/SCN9A activation (IC(50)=423 nM) (PubMed:25026046). {ECO:0000269|PubMed:10051143, ECO:0000269|PubMed:25026046}.

Target

voltage-gated sodium channel (Nav) voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Paraphysa scrofa (Chilean copper tarantula) (Phrixotrichus auratus)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Potent and specific blocker of Kv4.2/KCND2 (IC(50)=5 nM) and Kv4.3/KCND3 (IC(50)=28 nM) potassium channels (PubMed:10051143). Acts by altering the gating properties of these channels (PubMed:10051143).
Kappa-theraphotoxin-Ps1a (Kappa-TRTX-Ps1a) (PaTx1) (Phrixotoxin-1)
spider
Neurotoxin 30 (phrixotoxin) family
Evidence at protein level
3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:10051143}.
Additional Detail Fields 7 fields
3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Neurotoxin 30 (phrixotoxin) family
Kappa-theraphotoxin-Ps1a (Kappa-TRTX-Ps1a) (PaTx1) (Phrixotoxin-1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:10051143}.
spider