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Peptide record

TPDB27745

Neurotoxin Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB27745
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
VSCEDCPEHCSTQKAQAKCDNDKCVCEPI
Physicochemical Analysis
C125H203N37O48S6
RGLMFWY
C
3184.57
4.37
4
6
5
-3
14.61
-0.703
40.34
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
375
11.78
12
Residue Composition
number
2
A
0
R
1
N
3
D
6
C
3
E
2
Q
0
G
1
H
1
I
0
L
3
K
0
M
0
F
2
P
2
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 3 C: 6 E: 3 Q: 2 G: 0 H: 1 I: 1 L: 0 K: 3 M: 0 F: 0 P: 2 S: 2 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
29
C125H203N37O48S6
3184.57
4.37
-3
14.61
-0.703
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocker for the small conductance calcium-activated potassium channels (KCa2). {ECO:0000269|PubMed:8985784}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Androctonus mauritanicus mauritanicus (Scorpion)
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Blocker for the small conductance calcium-activated potassium channels (KCa2)..
Potassium channel toxin alpha-KTx 8.1 (AmP01) (P01) (PO1)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 08 subfamily
Evidence at protein level
3D-structure Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:8985784}.
Additional Detail Fields 7 fields
3D-structure Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 08 subfamily
Potassium channel toxin alpha-KTx 8.1 (AmP01) (P01) (PO1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:8985784}.
scorpion