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Peptide record

TPDB27735

Neurotoxin Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB27735
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GCMPEYCAGQCRGKVSQDYCLKNCRCIR
Physicochemical Analysis
C128H210N42O39S7
HFTW
C
3185.75
8.31
5
2
7
+3
5.33
-0.493
41.79
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3355
105.31
12
Residue Composition
number
1
A
3
R
1
N
1
D
6
C
1
E
2
Q
3
G
0
H
1
I
1
L
2
K
1
M
0
F
1
P
1
S
0
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 1 R: 3 N: 1 D: 1 C: 6 E: 1 Q: 2 G: 3 H: 0 I: 1 L: 1 K: 2 M: 1 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 2 V: 1
Chemical Descriptors
28
C128H210N42O39S7
3185.75
8.31
+3
5.33
-0.493
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks potassium channels Shaker-IR (with inactivation domain removed) and hKv1.2/KCNA2. {ECO:0000269|PubMed:22238341}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Tityus trivittatus (Argentinean scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Blocks potassium channels Shaker-IR (with inactivation domain removed) and hKv1.2/KCNA2..
Kappa-buthitoxin-Tt2b (Kappa-BUTX-Tt2b)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 20 subfamily
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 20 subfamily
Kappa-buthitoxin-Tt2b (Kappa-BUTX-Tt2b)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
scorpion