TPDB

3D PDB MODEL

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TPDB ID TPDB27731

Activity

Antiviral Neurotoxin Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AVPpred-BWR NTxPred2 pep-lab Peptipedia ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 27-aa standard natural multi-activity (Antiviral, Neurotoxin, and Toxicity) peptide sequence curated from AVPpred-BWR, NTxPred2, pep-lab, and other sources, with an available 3D structural model.

Sequence

RSCCPCYWGGCPWGQNCYPEGCSGPKV

FASTA

>TPDB27731|Antiviral;Neurotoxin;Toxicity|length=27
RSCCPCYWGGCPWGQNCYPEGCSGPKV

Formula C125H177N35O36S6

Absent Amino Acids ADHILMFT

Common Amino Acids C

Mass 2938.35

PI 7.62

Basic Residues 2

Acidic Residues 1

Hydrophobic Residues 5

Net Charge +1

Boman Index -0.02

Hydrophobicity -0.522

Aliphatic Index 10.74

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 14355

Absorbance 280nm 488.54

Polar Residues 12

number

0

A

1

R

1

N

0

D

6

C

1

E

1

Q

5

G

0

H

0

I

0

L

1

K

0

M

0

F

4

P

2

S

0

T

2

W

2

Y

1

V

Amino Acid Distribution

A: 0 R: 1 N: 1 D: 0 C: 6 E: 1 Q: 1 G: 5 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 4 S: 2 T: 0 W: 2 Y: 2 V: 1

Length

27

Formula

C125H177N35O36S6

Mass

2938.35

PI

7.62

Net Charge

+1

Boman Index

-0.02

Hydrophobicity

-0.522

Evidence 1 Activity

Activity

Detail Source Activity Neurotoxin

Function Text

FUNCTION: Specific arthropod (crab and insect) toxin that inhibits inactivation of voltage-gated sodium channels. It competes well with the site-3 toxin LqhalphaIT (from the scorpion L.quinquestriatus (AC P17728)) on binding to cockroach neuronal membranes (Ki=21.4 nM), and inhibits the inactivation of D.melanogaster channel (DmNav1), but not that of mammalian Navs expressed in Xenopus oocytes. Its activity is synergically enhanced by ligands of receptor site-4 (Bj-xtrIT (AC P56637)). Its ability to inhibit the channel mutant DmNav1[D1701R] only decreases 5-fold, whereas the inhibition activity is completely lost by LqhalphaIT and Av2 when tested on DmNav1[D1701R]. {ECO:0000269|PubMed:17492942, ECO:0000269|PubMed:19609479, ECO:0000269|PubMed:2409523}.

Target

Target or Channel voltage-gated sodium channel (Nav)

Source & Reference

Database Source NA

Source UniProtKB/Swiss-Prot Tox-Prot

Other

Organism Source Anemonia sulcata (Mediterranean snakelocks sea anemone)

Neurotoxin Type Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin

Mechanism

Specific arthropod (crab and insect) toxin that inhibits inactivation of voltage-gated sodium channels. It competes well with the site-3 toxin LqhalphaIT (from the scorpion L.quinquestriatus (AC P17728)) on binding to cockroach neuronal membranes (Ki=21.4 nM), and inhibits the inactivation of D.melanogaster channel (DmNav1), but not that of mammalian Navs expressed in Xenopus oocytes.

Protein Name Delta-actitoxin-Avd2a (Delta-AITX-Avd2a) (ATX III) (Av3) (Neurotoxin 3) (Neurotoxin III)

Venom Taxon Group sea anemone

Protein Family Sea anemone short toxin (type III) family

Protein Existence Evidence at protein level

Keywords 3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin

Keywords

3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin

Neurotoxin_Type

Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin

Protein_Existence

Evidence at protein level

Protein_Family

Sea anemone short toxin (type III) family

Protein_Name

Delta-actitoxin-Avd2a (Delta-AITX-Avd2a) (ATX III) (Av3) (Neurotoxin 3) (Neurotoxin III)

Venom_Taxon_Group

sea anemone