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Peptide record

TPDB27728

Neurotoxin Toxicity standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB27728
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 27-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
DPCYEVCLQQHGNVKECEEACKHPVEY
Physicochemical Analysis
C133H200N36O45S4
RIMFSTW
E
3151.51
4.48
4
6
7
-4
14.36
-0.878
50.37
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
3230
102.49
9
Residue Composition
number
1
A
0
R
1
N
1
D
4
C
5
E
2
Q
1
G
2
H
0
I
1
L
2
K
0
M
0
F
2
P
0
S
0
T
0
W
2
Y
3
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 1 C: 4 E: 5 Q: 2 G: 1 H: 2 I: 0 L: 1 K: 2 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 2 V: 3
Chemical Descriptors
27
C133H200N36O45S4
3151.51
4.48
-4
14.36
-0.878
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: OmTx1 decreases the amplitude of the potassium current of the rat channels Kv1.1/KCNA1 by 17% and Kv1.2/KCNA2 by 12% as well as human Kv1.3/KCNA3 by 24%. {ECO:0000269|PubMed:15631621}. FUNCTION: OmTx2 decreases the amplitude of the potassium current of the rat channels Kv1.1/KCNA1 by 8% and Kv1.2/KCNA2 by 10% as well as human Kv1.3/KCNA3 by 36%. Also alters glucose-induced insulin release from pancreatic islets. {ECO:0000269|PubMed:15631621}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Opisthacanthus madagascariensis (Scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
OmTx1 decreases the amplitude of the potassium current of the rat channels Kv1.1/KCNA1 by 17% and Kv1.2/KCNA2 by 12% as well as human Kv1.3/KCNA3 by 24%.. FUNCTION: OmTx2 decreases the amplitude of the potassium current of the rat channels Kv1.1/KCNA1 by 8% and Kv1.2/KCNA2 by 10% as well as human Kv1.3/KCNA3 by 36%. Also alters glucose-induced insulin release from pancreatic islets..
Potassium channel toxin kappa-KTx 2.2 (Toxin OmTx2) [Cleaved into: Potassium channel toxin kappa-KTx 2.1 (Toxin OmTx1) Potassium channel toxin kappa-KTx 2.4 (Toxin OmTx4)]
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor kappa-KTx family, Kappa-KTx 2 subfamily
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:15631621}.
Additional Detail Fields 7 fields
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor kappa-KTx family, Kappa-KTx 2 subfamily
Potassium channel toxin kappa-KTx 2.2 (Toxin OmTx2) [Cleaved into: Potassium channel toxin kappa-KTx 2.1 (Toxin OmTx1) Potassium channel toxin kappa-KTx 2.4 (Toxin OmTx4)]
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:15631621}.
scorpion