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Peptide record

TPDB27722

Neurotoxin Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB27722
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 26-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
CKQAGESCDIFSQNCCVGTCAFICIE
Physicochemical Analysis
C113H178N30O39S6
RHLMPWY
C
2773.19
3.83
1
3
8
-2
3.36
0.535
63.85
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
375
13.52
12
Residue Composition
number
2
A
0
R
1
N
1
D
6
C
2
E
2
Q
2
G
0
H
3
I
0
L
1
K
0
M
2
F
0
P
2
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 1 C: 6 E: 2 Q: 2 G: 2 H: 0 I: 3 L: 0 K: 1 M: 0 F: 2 P: 0 S: 2 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
26
C113H178N30O39S6
2773.19
3.83
-2
3.36
0.535
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Delta-conotoxins bind to site 6 of voltage-gated sodium channels (Nav) and inhibit the inactivation process. {ECO:0000269|PubMed:14550575}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus amadis (Amadis cone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Delta-conotoxins bind to site 6 of voltage-gated sodium channels (Nav) and inhibit the inactivation process..
Delta-conotoxin Am2766 (Am 2766) (Delta-Am2766)
cone snail
Conotoxin O1 superfamily
Evidence at protein level
3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:14550575}.
Additional Detail Fields 7 fields
3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Conotoxin O1 superfamily
Delta-conotoxin Am2766 (Am 2766) (Delta-Am2766)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:14550575}.
cone snail