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Peptide record

TPDB27711

Neurotoxin Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB27711
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 24-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GPPCCLYGSCRPFPGCYNALCCRK
Physicochemical Analysis
C111H170N32O29S6
DEQHIMTWV
C
2609.13
8.31
3
0
6
+3
-0.75
-0.008
36.67
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3355
128.59
10
Residue Composition
number
1
A
2
R
1
N
0
D
6
C
0
E
0
Q
3
G
0
H
0
I
2
L
1
K
0
M
1
F
4
P
1
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 1 D: 0 C: 6 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 2 K: 1 M: 0 F: 1 P: 4 S: 1 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
24
C111H170N32O29S6
2609.13
8.31
+3
-0.75
-0.008
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Psi-conotoxins act on postsynaptic membranes, and act as non-competitive antagonist of nicotinic acetylcholine receptors (nAChR). Is less toxic than Psi-conotoxin PIIIE. {ECO:0000269|PubMed:12767216}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus purpurascens (Purple cone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Psi-conotoxins act on postsynaptic membranes, and act as non-competitive antagonist of nicotinic acetylcholine receptors (nAChR). Is less toxic than Psi-conotoxin PIIIE..
Psi-conotoxin PIIIF
cone snail
Conotoxin M superfamily
Evidence at protein level
3D-structure Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:12767216}.
Additional Detail Fields 7 fields
3D-structure Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Conotoxin M superfamily
Psi-conotoxin PIIIF
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:12767216}.
cone snail