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Peptide record

TPDB27709

Neurotoxin Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB27709
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 23-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
NDPCEEVCLQHTGNVKACEEACQ
Physicochemical Analysis
C99H158N30O39S4
RIMFSWY
CE
2520.76
4.00
2
5
5
-4
12.14
-0.674
50.87
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
250
9.92
9
Residue Composition
number
2
A
0
R
2
N
1
D
4
C
4
E
2
Q
1
G
1
H
0
I
1
L
1
K
0
M
0
F
1
P
0
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 2 D: 1 C: 4 E: 4 Q: 2 G: 1 H: 1 I: 0 L: 1 K: 1 M: 0 F: 0 P: 1 S: 0 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
23
C99H158N30O39S4
2520.76
4.00
-4
12.14
-0.674
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Decreases the amplitude of the potassium current of the rat channels Kv1.1/KCNA1 by 33% and Kv1.2/KCNA2 by 8% as well as human Kv1.3/KCNA3 by 70%. {ECO:0000269|PubMed:15631621}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Opisthacanthus madagascariensis (Scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Decreases the amplitude of the potassium current of the rat channels Kv1.1/KCNA1 by 33% and Kv1.2/KCNA2 by 8% as well as human Kv1.3/KCNA3 by 70%..
Potassium channel toxin kappa-KTx 2.3 (Toxin OmTx3)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor kappa-KTx family, Kappa-KTx 2 subfamily
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:15631621}.
Additional Detail Fields 7 fields
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor kappa-KTx family, Kappa-KTx 2 subfamily
Potassium channel toxin kappa-KTx 2.3 (Toxin OmTx3)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:15631621}.
scorpion