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Peptide record

TPDB27708

Neurotoxin Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB27708
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 23-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
ACGSCRKKCKGSGKCINGRCKCY
Physicochemical Analysis
C96H169N35O28S6
DEQHLMFPTWV
C
2453.98
9.61
7
0
3
+7
4.43
-0.661
21.30
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1865
76.00
10
Residue Composition
number
1
A
2
R
1
N
0
D
6
C
0
E
0
Q
4
G
0
H
1
I
0
L
5
K
0
M
0
F
0
P
2
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 1 D: 0 C: 6 E: 0 Q: 0 G: 4 H: 0 I: 1 L: 0 K: 5 M: 0 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
23
C96H169N35O28S6
2453.98
9.61
+7
4.43
-0.661
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks reversibly Shaker B potassium channels. Also displaces binding of noxiustoxin to mouse brain synaptosome membranes. {ECO:0000269|PubMed:11113450}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Tityus obscurus (Amazonian scorpion) (Tityus cambridgei)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Blocks reversibly Shaker B potassium channels. Also displaces binding of noxiustoxin to mouse brain synaptosome membranes..
Potassium channel toxin alpha-KTx 13.1 (Toxin Tc1) (Toxin To1)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 13 subfamily
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:15025998, ECO:0000305}.
Additional Detail Fields 7 fields
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 13 subfamily
Potassium channel toxin alpha-KTx 13.1 (Toxin Tc1) (Toxin To1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:15025998, ECO:0000305}.
scorpion