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Peptide record

TPDB27707

Neurotoxin Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB27707
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 22-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
RDCCTPPRKCKDRRCKPMKCCA
Physicochemical Analysis
C101H180N38O28S7
NEQGHILFSWYV
C
2599.20
9.32
8
2
2
+6
9.31
-1.245
4.55
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
375
14.43
7
Residue Composition
number
1
A
4
R
0
N
2
D
6
C
0
E
0
Q
0
G
0
H
0
I
0
L
4
K
1
M
0
F
3
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 4 N: 0 D: 2 C: 6 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 4 M: 1 F: 0 P: 3 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
22
C101H180N38O28S7
2599.20
9.32
+6
9.31
-1.245
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Mu-conotoxins block voltage-gated sodium channels (Nav). {ECO:0000250|UniProtKB:P01523}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus geographus (Geography cone) (Nubecula geographus)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Mu-conotoxins block voltage-gated sodium channels (Nav)..
Mu-conotoxin GIIIB (Geographutoxin II) (GTx-II) (Myotoxin II)
cone snail
Conotoxin M superfamily
Evidence at protein level
3D-structure Amidation Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:6852238, ECO:0000305|PubMed:8688418}.
Additional Detail Fields 7 fields
3D-structure Amidation Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Conotoxin M superfamily
Mu-conotoxin GIIIB (Geographutoxin II) (GTx-II) (Myotoxin II)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:6852238, ECO:0000305|PubMed:8688418}.
cone snail