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Peptide record

TPDB27703

Neurotoxin Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB27703
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 22-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
QGCCNGPKGCSSKWCRDHARCC
Physicochemical Analysis
C92H147N35O29S6
EILMFTYV
C
2399.76
8.32
5
1
2
+3
4.07
-0.864
4.55
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
5875
244.82
10
Residue Composition
number
1
A
2
R
1
N
1
D
6
C
0
E
1
Q
3
G
1
H
0
I
0
L
2
K
0
M
0
F
1
P
2
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 1 D: 1 C: 6 E: 0 Q: 1 G: 3 H: 1 I: 0 L: 0 K: 2 M: 0 F: 0 P: 1 S: 2 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
22
C92H147N35O29S6
2399.76
8.32
+3
4.07
-0.864
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Mu-conotoxins block voltage-gated sodium channels (Nav). This synthetic toxin blocks both voltage-gated sodium channels and nicotinic acetylcholine receptor (nAChR). Inhibits the skeletal muscle rNav1.4/SCN4A (IC(50)=1.3 nM) and the brain rNav1.2/SCN2A in a long-lasting manner. A low inhibition is also observed on neuronal mNav1.6/SCN8A and mNav1.7/SCN9A. Modestly blocks nAChR alpha-3/beta-2 subtype (IC(50)=450 nM) (partially reversible) and, to a lesser extent, alpha-7 and alpha-4/beta-2 subtypes (reversible). In vitro, decreases twitch tension in mouse hemidiaphragms (IC(50)=150 nM), and displays a high blocking effect in mouse extensor digitorum longus muscles (IC(50)=46 nM). {ECO:0000269|PubMed:22229737}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus consors (Singed cone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Mu-conotoxins block voltage-gated sodium channels (Nav). This synthetic toxin blocks both voltage-gated sodium channels and nicotinic acetylcholine receptor (nAChR).
Mu-conotoxin CnIIIC
cone snail
Conotoxin M superfamily
Evidence at protein level
3D-structure Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Pyrrolidone carboxylic acid Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
3D-structure Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Pyrrolidone carboxylic acid Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Conotoxin M superfamily
Mu-conotoxin CnIIIC
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail