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Peptide record

TPDB27700

Neurotoxin Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB27700
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 21-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
TRICCGCYWNGSKDVCSQSCC
Physicochemical Analysis
C91H142N28O31S6
AEHLMFP
C
2316.66
7.62
2
1
4
+1
0.11
-0.062
32.38
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
7365
317.91
13
Residue Composition
number
0
A
1
R
1
N
1
D
6
C
0
E
1
Q
2
G
0
H
1
I
0
L
1
K
0
M
0
F
0
P
3
S
1
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 1 C: 6 E: 0 Q: 1 G: 2 H: 0 I: 1 L: 0 K: 1 M: 0 F: 0 P: 0 S: 3 T: 1 W: 1 Y: 1 V: 1
Chemical Descriptors
21
C91H142N28O31S6
2316.66
7.62
+1
0.11
-0.062
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Injections of 20 uM of this synthetic peptide (Ile) causes partial paralysis to polychaete worms (Nereis virens), the natural prey of terebrid snails (PubMed:24713808). This paralysis may be due to an inhibition of nicotinic receptors at the neuromuscular junction (Probable). {ECO:0000269|PubMed:24713808, ECO:0000305|PubMed:24713808}.

Target

acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Terebra variegata (Variegate auger snail)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin
Injections of 20 uM of this synthetic peptide (Ile) causes partial paralysis to polychaete worms (Nereis virens), the natural prey of terebrid snails (PubMed:24713808). This paralysis may be due to an inhibition of nicotinic receptors at the neuromuscular junction (Probable)..
Venom peptide Tv1 (Teretoxin v3a)
other
Evidence at protein level
3D-structure Acetylcholine receptor inhibiting toxin Direct protein sequencing Disulfide bond Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the salivary gland. This peptide is considered as a venom peptide. {ECO:0000305|PubMed:24713808}.
Additional Detail Fields 6 fields
3D-structure Acetylcholine receptor inhibiting toxin Direct protein sequencing Disulfide bond Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin
Evidence at protein level
Venom peptide Tv1 (Teretoxin v3a)
TISSUE SPECIFICITY: Expressed by the salivary gland. This peptide is considered as a venom peptide. {ECO:0000305|PubMed:24713808}.
other