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Peptide record

TPDB27699

Neurotoxin Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB27699
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 21-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GEEEYQKMLENLREAEVKKNA
Physicochemical Analysis
C106H174N30O38S1
DCHIFPSTW
E
2508.79
4.55
4
6
7
-2
14.77
-1.529
60.48
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
59.39
4
Residue Composition
number
2
A
1
R
2
N
0
D
0
C
6
E
1
Q
1
G
0
H
0
I
2
L
3
K
1
M
0
F
0
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 1 N: 2 D: 0 C: 0 E: 6 Q: 1 G: 1 H: 0 I: 0 L: 2 K: 3 M: 1 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
21
C106H174N30O38S1
2508.79
4.55
-2
14.77
-1.529
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors. This toxin inhibits both NR2A/GRIN2A and NR2B/GRIN2B subunits of N-methyl-D-aspartate (NMDA) receptor-mediated calcium influx in central nervous system neurons. Induces sleep-like symptoms in young mice and hyperactivity in older mice. {ECO:0000269|PubMed:2165278}.

Target

glutamate receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus tulipa (Fish-hunting cone snail) (Tulip cone)
Neurotoxin Postsynaptic neurotoxin Ion channel impairing toxin Ionotropic glutamate receptor inhibitor
Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors. This toxin inhibits both NR2A/GRIN2A and NR2B/GRIN2B subunits of N-methyl-D-aspartate (NMDA) receptor-mediated calcium influx in central nervous system neurons.
Conantokin-T (Con-T)
cone snail
Conotoxin B superfamily
Evidence at protein level
3D-structure Amidation Calcium Direct protein sequencing Gamma-carboxyglutamic acid Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Magnesium Metal-binding Neurotoxin Pharmaceutical Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305}.
Additional Detail Fields 7 fields
3D-structure Amidation Calcium Direct protein sequencing Gamma-carboxyglutamic acid Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Magnesium Metal-binding Neurotoxin Pharmaceutical Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Ion channel impairing toxin Ionotropic glutamate receptor inhibitor
Evidence at protein level
Conotoxin B superfamily
Conantokin-T (Con-T)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305}.
cone snail