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Peptide record

TPDB27697

Neurotoxin Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB27697
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 21-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
ALCNCNRIIIPHMCWKKCGKK
Physicochemical Analysis
C106H179N33O24S5
DEQFSTYV
CK
2460.09
9.75
6
0
7
+5
2.33
-0.105
79.05
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5750
233.73
6
Residue Composition
number
1
A
1
R
2
N
0
D
4
C
0
E
0
Q
1
G
1
H
3
I
1
L
4
K
1
M
0
F
1
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 2 D: 0 C: 4 E: 0 Q: 0 G: 1 H: 1 I: 3 L: 1 K: 4 M: 1 F: 0 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
21
C106H179N33O24S5
2460.09
9.75
+5
2.33
-0.105
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Presynaptic neurotoxin that blocks the inwardly rectifying Kir1.1/KCNJ1 and Kir3.1/3.4 (KCNJ3/KCNJ5) potassium channels with high affinity by binding to the M1-M2 linker region of these channels in a 1:1 stoichiometry. It may block the potassium channel pore by occluding its alpha helix into the channel vestibule. Tertiapin-Q also inhibits calcium-activated large conductance BK-type (KCNMA) potassium channels in a concentration-, and voltage-dependent manner, in addition to inhibiting Kir3.1/3.2 (KCNJ3/KCNJ6) heteromultimers potassium channels. It can prevent dose-dependently acetylcholine(ACh)-induced atrioventricular blocks in mammalian hearts, as KCNJ3/KCNJ5 channels (also named I(KACh), because these channels are activated by ACh) are found in mammalian myocytes. Interacts specifically with calmodulin in the presence of calcium. {ECO:0000269|PubMed:10572004, ECO:0000269|PubMed:10734170, ECO:0000269|PubMed:11015309, ECO:0000269|PubMed:16725344, ECO:0000269|PubMed:6091685, ECO:0000269|PubMed:9748337}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Apis mellifera (Honeybee)
Neurotoxin Presynaptic neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Presynaptic neurotoxin that blocks the inwardly rectifying Kir1.1/KCNJ1 and Kir3.1/3.4 (KCNJ3/KCNJ5) potassium channels with high affinity by binding to the M1-M2 linker region of these channels in a 1:1 stoichiometry. It may block the potassium channel pore by occluding its alpha helix into the channel vestibule.
Tertiapin (TPN)
insect
Evidence at protein level
3D-structure Calcium-activated potassium channel impairing toxin Calmodulin-binding Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Oxidation Potassium channel impairing toxin Presynaptic neurotoxin Reference proteome Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:9748337, ECO:0000305|Ref.1}.
Additional Detail Fields 6 fields
3D-structure Calcium-activated potassium channel impairing toxin Calmodulin-binding Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Oxidation Potassium channel impairing toxin Presynaptic neurotoxin Reference proteome Secreted Toxin
Neurotoxin Presynaptic neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Tertiapin (TPN)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:9748337, ECO:0000305|Ref.1}.
insect