Back to search

Peptide record

TPDB27690

Neurotoxin Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB27690
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 18-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
EGCCSNPACRTNHPEVCD
Physicochemical Analysis
C73H115N25O29S4
QILKMFWY
C
1935.11
4.42
2
3
2
-2
8.00
-0.794
21.67
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
250
12.92
8
Residue Composition
number
1
A
1
R
2
N
1
D
4
C
2
E
0
Q
1
G
1
H
0
I
0
L
0
K
0
M
0
F
2
P
1
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 2 D: 1 C: 4 E: 2 Q: 0 G: 1 H: 1 I: 0 L: 0 K: 0 M: 0 F: 0 P: 2 S: 1 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
18
C73H115N25O29S4
1935.11
4.42
-2
8.00
-0.794
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This peptide is active on neuronal nAChRs alpha-7/CHRNA7 (IC(50) of 3.24 uM), alpha-3-beta-4/CHRNA3-CHRNB4, alpha-4-beta-2/CHRNA4-CHRNB2, and alpha-4-beta-4/CHRNA4-CHRNB4. 10 uM of this peptide inhibits these receptors by 85%, 40%, 19%, and 13%, respectively. {ECO:0000269|PubMed:24567324}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conasprella longurionis (Cone snail) (Conus longurionis)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This peptide is active on neuronal nAChRs alpha-7/CHRNA7 (IC(50) of 3.24 uM), alpha-3-beta-4/CHRNA3-CHRNB4, alpha-4-beta-2/CHRNA4-CHRNB2, and alpha-4-beta-4/CHRNA4-CHRNB4.
Alpha-conotoxin Lo1a
cone snail
Conotoxin A superfamily
Evidence at protein level
3D-structure Acetylcholine receptor inhibiting toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:24567324}.
Additional Detail Fields 7 fields
3D-structure Acetylcholine receptor inhibiting toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin Lo1a
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:24567324}.
cone snail