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Peptide record

TPDB27687

Antiviral Neurotoxin Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB27687
Antiviral Neurotoxin Toxicity
Anti-infective peptides Toxicity and safety peptides
AVPpred-BWR NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 17-aa standard natural multi-activity (Antiviral, Neurotoxin, and Toxicity) peptide sequence curated from AVPpred-BWR, NTxPred2, pep-lab, and other sources, with an available 3D structural model.
Sequence
GCCSHPACNVNNPHICG
Physicochemical Analysis
C67H104N24O22S4
RDEQLKMFTWY
C
1725.95
7.00
2
0
3
+0
2.86
-0.071
45.88
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
250
14.48
8
Residue Composition
number
1
A
0
R
3
N
0
D
4
C
0
E
0
Q
2
G
2
H
1
I
0
L
0
K
0
M
0
F
2
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 3 D: 0 C: 4 E: 0 Q: 0 G: 2 H: 2 I: 1 L: 0 K: 0 M: 0 F: 0 P: 2 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
17
C67H104N24O22S4
1725.95
7.00
+0
2.86
-0.071
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks alpha-3-beta-2/CHRNA3-CHRNB2 (IC(50)=11 nM), alpha-7/CHRNA7 (IC(50)=27.1-59 nM (rat)/ 290 nM (human)), alpha-3-beta-4/CHRNA3-CHRNB4 (IC(50)=160 nM), and alpha-6/alpha-3-beta-2-beta-3 (CHRNA6/CHRNA3-CHRNB2-CHRNB3) (IC(50)=201 nM) nAChR (PubMed:16803900, PubMed:30025921, PubMed:34955864). In the OmIA-AChBP complex, this toxin occupies all five binding pockets located between two adjacent subunits of the homopentamer (PubMed:34955864). Despite a competitive binding mode observed in the co-crystal structure, it displays functional insurmountable antagonism at alpha-7 and alpha-3-beta-4 nAChRs (PubMed:34955864). It also shows biphasic-inhibition at alpha-7 nAChRs in the presence of the positive allosteric modulator PNU120596, with a preference for the high-affinity binding site following prolonged exposure (PubMed:34955864). {ECO:0000269|PubMed:16803900, ECO:0000269|PubMed:30025921, ECO:0000269|PubMed:34955864}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus omaria (Omaria cone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks alpha-3-beta-2/CHRNA3-CHRNB2 (IC(50)=11 nM), alpha-7/CHRNA7 (IC(50)=27.1-59 nM (rat)/ 290 nM (human)), alpha-3-beta-4/CHRNA3-CHRNB4 (IC(50)=160 nM), and alpha-6/alpha-3-beta-2-beta-3 (CHRNA6/CHRNA3-CHRNB2-CHRNB3) (IC(50)=201 nM) nAChR (PubMed:16803900, PubMed:30025921, PubMed:34955864).
Alpha-conotoxin OmIA
cone snail
Conotoxin A superfamily
Evidence at protein level
3D-structure Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:16803900}.
Additional Detail Fields 7 fields
3D-structure Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin OmIA
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:16803900}.
cone snail