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Peptide record

TPDB27686

Neurotoxin Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB27686
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 16-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
WCASGCRKKRHGGCSC
Physicochemical Analysis
C68H111N27O19S4
NDEQILMFPTYV
C
1739.04
9.29
5
0
2
+4
1.87
-0.744
6.25
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5750
330.64
6
Residue Composition
number
1
A
2
R
0
N
0
D
4
C
0
E
0
Q
3
G
1
H
0
I
0
L
2
K
0
M
0
F
0
P
2
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 0 C: 4 E: 0 Q: 0 G: 3 H: 1 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 2 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
16
C68H111N27O19S4
1739.04
9.29
+4
1.87
-0.744
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Weakly inhibits human L-type voltage-gated calcium channel Cav1 (CACNA1S, CACNA1C, CACNA1D, CACNA1F) (IC(50)=4.6 uM). In vivo, it induces reversible paralysis in blowfly L.cuprina. {ECO:0000269|PubMed:27474999}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Anochetus emarginatus (Ant) (Stenomyrmex emarginatus)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Weakly inhibits human L-type voltage-gated calcium channel Cav1 (CACNA1S, CACNA1C, CACNA1D, CACNA1F) (IC(50)=4.6 uM). In vivo, it induces reversible paralysis in blowfly L.cuprina..
U1-poneritoxin-Ae1a (U1-PONTX-Ae1a) (Poneratoxin)
insect
Poneritoxin-Ae1 family
Evidence at protein level
3D-structure Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:27474999}.
Additional Detail Fields 7 fields
3D-structure Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Poneritoxin-Ae1 family
U1-poneritoxin-Ae1a (U1-PONTX-Ae1a) (Poneratoxin)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:27474999}.
insect