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Peptide record

TPDB27681

Neurotoxin Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB27681
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 16-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GCCSLPPCAANNPDYC
Physicochemical Analysis
C65H98N18O23S4
REQHIKMFTWV
C
1627.84
3.10
0
1
4
-1
0.76
-0.025
36.88
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1740
106.89
8
Residue Composition
number
2
A
0
R
2
N
1
D
4
C
0
E
0
Q
1
G
0
H
0
I
1
L
0
K
0
M
0
F
3
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 2 D: 1 C: 4 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 3 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
16
C65H98N18O23S4
1627.84
3.10
-1
0.76
-0.025
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks mammalian alpha-3-beta-2/CHRNA3-CHRNB2 (IC(50)=7-68 nM) and alpha-7/CHRNA7 (IC(50)=253 nM) nAChRs (PubMed:10545176, PubMed:15929983, PubMed:22024738, PubMed:25101833, PubMed:8068627). It also shows a high inhibition on alpha-6/alpha-3-beta-2-beta-3 (CHRNA6/CHRNA3-CHRNB2-CHRNB3) (IC(50)=11 nM) and a low inhibition on alpha-6-beta-4/CHRNA4-CHRNB4 (IC(50)>500 nM) (PubMed:22024738). It interacts with a hydrophobic pocket between two acetylcholine receptor subunits. In vivo, inhibits Ehrlich carcinoma growth and increase mouse survival (PubMed:32272633). These effects are greatly enhanced when the toxin is applied with the selective 12-lipoxygenase inhibitor baicalein (PubMed:32272633). {ECO:0000269|PubMed:10545176, ECO:0000269|PubMed:12734390, ECO:0000269|PubMed:15929983, ECO:0000269|PubMed:22024738, ECO:0000269|PubMed:25101833, ECO:0000269|PubMed:8068627}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus pennaceus (Feathered cone) (Conus episcopus)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks mammalian alpha-3-beta-2/CHRNA3-CHRNB2 (IC(50)=7-68 nM) and alpha-7/CHRNA7 (IC(50)=253 nM) nAChRs (PubMed:10545176, PubMed:15929983, PubMed:22024738, PubMed:25101833, PubMed:8068627).
Alpha-conotoxin PnIA (Alpha-PnIA)
cone snail
Conotoxin A superfamily
Evidence at protein level
3D-structure Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Sulfation Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:8068627}.
Additional Detail Fields 7 fields
3D-structure Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Sulfation Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin PnIA (Alpha-PnIA)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:8068627}.
cone snail