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Peptide record

TPDB27666

Neurotoxin Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB27666
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
VGVCCGYKLCHPC
Physicochemical Analysis
C58H92N16O15S4
ARNDEQIMFSTW
C
1381.71
7.85
2
0
4
+1
0.10
0.877
74.62
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
1740
125.93
5
Residue Composition
number
0
A
0
R
0
N
0
D
4
C
0
E
0
Q
2
G
1
H
0
I
1
L
1
K
0
M
0
F
1
P
0
S
0
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 4 E: 0 Q: 0 G: 2 H: 1 I: 0 L: 1 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 2
Chemical Descriptors
13
C58H92N16O15S4
1381.71
7.85
+1
0.10
0.877
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Chi-conotoxins inhibit the neuronal noradrenaline transporter (NET/SLC6A2). {ECO:0000269|PubMed:11528421}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus marmoreus (Marble cone)
Neurotoxin
Chi-conotoxins inhibit the neuronal noradrenaline transporter (NET/SLC6A2)..
Chi-conotoxin MrIB (Conotoxin MrIB) (Lambda/chi-conotoxin MrIB) (Chi-MrIB)
cone snail
Conotoxin T superfamily
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Hydroxylation Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:11528421}.
Additional Detail Fields 7 fields
3D-structure Direct protein sequencing Disulfide bond Hydroxylation Neurotoxin Secreted Toxin
Neurotoxin
Evidence at protein level
Conotoxin T superfamily
Chi-conotoxin MrIB (Conotoxin MrIB) (Lambda/chi-conotoxin MrIB) (Chi-MrIB)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:11528421}.
cone snail