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Peptide record

TPDB27664

Neurotoxin Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB27664
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
ICCNPACGPKYSC
Physicochemical Analysis
C55H87N15O17S4
RDEQHLMFTWV
C
1358.63
7.84
1
0
3
+1
0.07
0.246
37.69
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
1740
128.07
7
Residue Composition
number
1
A
0
R
1
N
0
D
4
C
0
E
0
Q
1
G
0
H
1
I
0
L
1
K
0
M
0
F
2
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 4 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 1 M: 0 F: 0 P: 2 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
13
C55H87N15O17S4
1358.63
7.84
+1
0.07
0.246
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. Is active on muscle nAChR. On mice muscle receptors, its higher affinity site is the alpha/delta nAChR subunit interface. On Torpedo receptors, it does not distinguish between alpha/delta and alpha/gamma acetylcholine-binding sites. In vivo, causes paralysis followed by death when injected into goldfish. In contrast, has no effect on mice, when similar doses are intraperitoneally or intracerebrally injected. {ECO:0000250|UniProtKB:P15471}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus obscurus (Obscure cone) (Conus halitropus)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. Is active on muscle nAChR.
Alpha-conotoxin OIB (Alpha-conotoxin SI-like)
cone snail
Conotoxin A superfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:36292948}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin OIB (Alpha-conotoxin SI-like)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:36292948}.
cone snail