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Peptide record

TPDB27659

Neurotoxin Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB27659
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 12-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GVCCGVSFCYPC
Physicochemical Analysis
C52H76N12O15S4
ARNDEQHILKMTW
C
1237.49
5.03
0
0
4
-0
-2.29
1.392
48.33
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1740
140.61
6
Residue Composition
number
0
A
0
R
0
N
0
D
4
C
0
E
0
Q
2
G
0
H
0
I
0
L
0
K
0
M
1
F
1
P
1
S
0
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 4 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 1 S: 1 T: 0 W: 0 Y: 1 V: 2
Chemical Descriptors
12
C52H76N12O15S4
1237.49
5.03
-0
-2.29
1.392
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits the neuronal noradrenaline transporter (NET/SLC6A2). {ECO:0000250|UniProtKB:P58808}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus araneosus (Cobweb cone)
Neurotoxin
Inhibits the neuronal noradrenaline transporter (NET/SLC6A2)..
Chi-conotoxin-like Ar1248 (Conotoxin Ar1232)
cone snail
Conotoxin T superfamily
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Hydroxylation Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:20843009}.
Additional Detail Fields 7 fields
3D-structure Direct protein sequencing Disulfide bond Hydroxylation Neurotoxin Secreted Toxin
Neurotoxin
Evidence at protein level
Conotoxin T superfamily
Chi-conotoxin-like Ar1248 (Conotoxin Ar1232)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:20843009}.
cone snail