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Peptide record

TPDB27656

Neurotoxin Toxicity standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB27656
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 9-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GDCPWKPWC
Physicochemical Analysis
C50H66N12O12S2
ARNEQHILMFSTYV
CPW
1091.27
5.94
1
1
2
-0
-1.05
-0.867
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11125
1019.46
2
Residue Composition
number
0
A
0
R
0
N
1
D
2
C
0
E
0
Q
1
G
0
H
0
I
0
L
1
K
0
M
0
F
2
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 1 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 2 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
9
C50H66N12O12S2
1091.27
5.94
-0
-1.05
-0.867
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Affects both voltage-gated (Kv) and calcium-dependent potassium channel activities (KCa), with composite and diversified effects in invertebrate and vertebrate systems (PubMed:12646193). In vivo, intramuscular injection in freshwater fishes (Poecelia pinnata) causes secretion of mucous substances, a reaction already observed in fish with other contryphans (PubMed:12646193). {ECO:0000269|PubMed:12646193}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus ventricosus (Mediterranean cone)
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Affects both voltage-gated (Kv) and calcium-dependent potassium channel activities (KCa), with composite and diversified effects in invertebrate and vertebrate systems (PubMed:12646193). In vivo, intramuscular injection in freshwater fishes (Poecelia pinnata) causes secretion of mucous substances, a reaction already observed in fish with other contryphans (PubMed:12646193)..
Contryphan-Vn
cone snail
O2 superfamily, Contryphan family
Evidence at protein level
3D-structure Amidation Calcium-activated potassium channel impairing toxin D-amino acid Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:11688995}.
Additional Detail Fields 7 fields
3D-structure Amidation Calcium-activated potassium channel impairing toxin D-amino acid Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
O2 superfamily, Contryphan family
Contryphan-Vn
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:11688995}.
cone snail