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Peptide record

TPDB27655

Neurotoxin Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB27655
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 12-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GCCSDPRCRYRC
Physicochemical Analysis
C53H87N21O17S4
ANEQHILKMFTWV
C
1418.64
8.31
3
1
1
+2
2.35
-0.925
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1740
122.65
6
Residue Composition
number
0
A
3
R
0
N
1
D
4
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
1
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 1 C: 4 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
12
C53H87N21O17S4
1418.64
8.31
+2
2.35
-0.925
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. {ECO:0000250|UniProtKB:P50983}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus regius (Crown cone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them..
Alpha-conotoxin-like Reg1e
cone snail
Conotoxin A superfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000269|PubMed:17153339}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin-like Reg1e
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000269|PubMed:17153339}.
cone snail