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Peptide record

TPDB27555

Antibacterial Anticancer Antiviral Toxicity modified_plain modified
28 amino acids
Basic Information
3D PDB MODEL
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TPDB27555
Antibacterial Anticancer Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia dbAMP 3.0 DRAVP 2.0
modified_plain
Yes
A 28-aa modified multi-activity (Antibacterial, Anticancer, Antiviral, and other sources) peptide sequence curated from Peptipedia, dbAMP 3.0, and DRAVP 2.0, with an available 3D structural model.
Modified, details unspecified
Sequence
YTSLIHSLIEESQNQQEKNEQELLELDX
Physicochemical Analysis
C138H220N36O53
ARCGMFPWV
E
3231.47
3.80
2
7
8
-6
14.63
-1.036
97.50
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
46.11
11
Residue Composition
number
0
A
0
R
2
N
1
D
0
C
6
E
4
Q
0
G
1
H
2
I
5
L
1
K
0
M
0
F
0
P
3
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 2 D: 1 C: 0 E: 6 Q: 4 G: 0 H: 1 I: 2 L: 5 K: 1 M: 0 F: 0 P: 0 S: 3 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
28
C138H220N36O53
3231.47
3.80
-6
14.63
-1.036
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Cytotoxicity
Toxicity
408±40.1 µM
Cytotoxic
50% Cytotoxicity | 408±40.1 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Structural and Functional Characterization of Membrane Fusion Inhibitors With Extremely Potent Activity Against Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus. | J Virol | 2018
Evidence 2 Activity

Activity

50% Cytotoxicity
Toxicity
212.6±25.71 µM
Cytotoxic
50% Cytotoxicity | 212.6±25.71 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Structural and Functional Characterization of Membrane Fusion Inhibitors With Extremely Potent Activity Against Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus. | J Virol | 2018
Evidence 3 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.30089693]TZM-bl cell:CC50=800.8 ± 62.29 µM ##MT-4 cell:CC50=366.3± 119.08 µM ##HEK293T cell:CC50=408± 40.1µM ##PBMC:CC50=212.6± 25.71 µM.

Source & Reference

NA
DRAMP
J Virol. 2018 Sep 26 92(20):e01088-18.