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Peptide record

TPDB27554

Antibacterial Anticancer Antiviral Toxicity standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB27554
Antibacterial Anticancer Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia AI4AVP dbAMP 3.0 DRAVP 2.0 PEPlife
standard
No
A 36-aa standard natural multi-activity (Antibacterial, Anticancer, Antiviral, and other sources) peptide sequence curated from Peptipedia, AI4AVP, dbAMP 3.0, and other sources, with an available 3D structural model.
Sequence
YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF
Physicochemical Analysis
C202H298N50O64
RCGMPV
EL
4450.88
4.07
3
7
14
-5
8.76
-0.875
89.44
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
17990
404.19
13
Residue Composition
number
1
A
0
R
3
N
1
D
0
C
6
E
4
Q
0
G
1
H
2
I
6
L
2
K
0
M
1
F
0
P
4
S
1
T
3
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 3 D: 1 C: 0 E: 6 Q: 4 G: 0 H: 1 I: 2 L: 6 K: 2 M: 0 F: 1 P: 0 S: 4 T: 1 W: 3 Y: 1 V: 0
Chemical Descriptors
36
C202H298N50O64
4450.88
4.07
-5
8.76
-0.875
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Cytotoxicity
Toxicity
187.28 µM
Cytotoxic
50% Cytotoxicity | 187.28 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Monotherapy With a Low-Dose Lipopeptide HIV Fusion Inhibitor Maintains Long-Term Viral Suppression in Rhesus Macaques. | PLoS Pathog | 2019
Evidence 2 Activity

Activity

50% Cytotoxicity
Toxicity
75.24 µM
Cytotoxic
50% Cytotoxicity | 75.24 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Monotherapy With a Low-Dose Lipopeptide HIV Fusion Inhibitor Maintains Long-Term Viral Suppression in Rhesus Macaques. | PLoS Pathog | 2019
Additional Detail Fields 6 fields
3.8 ± 0.6 hrs
7919.999999999999
hrs
-0.875
4491.876
4.3