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Peptide record

TPDB27522

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Kyotorphin Antibacterial Blood-Brain Barrier Neuropeptide iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB27522
dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Kyotorphin
Antibacterial Blood-Brain Barrier Neuropeptide iDPPIV
Anti-infective peptides Cardiometabolic peptides Delivery and barrier-penetrating peptides Neuroactive peptides
Peptipedia iDPPIV
standard
No
A 2-aa standard natural multi-activity (Antibacterial, Blood-Brain Barrier, Neuropeptide, and other sources) peptide sequence curated from Peptipedia and iDPPIV, with an available 3D structural model.
Sequence
YR
Physicochemical Analysis
C15H23N5O4
ANDCEQGHILKMFPSTWV
RY
337.38
9.88
1
0
1
+1
-0.13
-2.900
0.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
441.64
1
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
2
C15H23N5O4
337.38
9.88
+1
-0.13
-2.900
337.3733
Linear
337.1745
Similarity
Tyr-Arg
C1=CC(=CC=C1C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)N)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Blood-Brain Barrier

Assay & Model

Origin/Source

Source & Reference

NA
B3Pdb

Other

human
Evidence 2 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.
Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73, 2015
2015
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O InChI=1S/C15H23N5O4/c16-11(8-9-3-5-10(21)6-4-9)13(22)20-12(14(23)24)2-1-7-19-15(17)18/h3-6,11-12,21H,1-2,7-8,16H2,(H,20,22)(H,23,24)(H4,17,18,19)/t11-,12-/m0/s1 InChIKey=JXNRXNCCROJZFB-RYUDHWBXSA-N Inhibitor of Dipeptidyl peptidase III (DPP-III) (EC 3.4.14.4) (MEROPS ID: M49.003) according to the BIOPEP-UWM database of bioactive peptides (ID:9484) Antiinflammatory activity according to the ChEMBL database (ID CHEMBL273521) Neuropeptide according to the BIOPEP-UWM database of bioactive peptides (ID 9534) the ChEMBL database the EROP-Moscow database Information concerning Dipeptidyl peptidase IV (DPP IV) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: S09.003)
Additional Detail Fields 1 fields
2