TPDB

3D PDB MODEL

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TPDB ID TPDB27479

Peptide_Name

Peptide YY

Activity

Antibacterial Antifungal Neuropeptide Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides Neuroactive peptides

Database_Source

Peptipedia Antifungipept CAFPdb dbAMP

Sequence_Type

standard

Has_Modification No

Description A 36-aa standard natural multi-activity (Antibacterial, Antifungal, Neuropeptide, and other sources) peptide sequence curated from Peptipedia, Antifungipept, CAFPdb, and other sources, with an available 3D structural model.

Sequence

YPIKPEAPREDASPEELNRYYASLRHYLNLVTRQRY

FASTA

>TPDB27479|Antibacterial;Antifungal;Neuropeptide;Toxicity|length=36
YPIKPEAPREDASPEELNRYYASLRHYLNLVTRQRY

Formula C198H303N57O58

Absent Amino Acids CGMFW

Common Amino Acids RY

Mass 4409.93

PI 9.26

Basic Residues 7

Acidic Residues 5

Hydrophobic Residues 14

Net Charge +1

Boman Index 11.24

Hydrophobicity -1.208

Aliphatic Index 70.56

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 7450

Absorbance 280nm 168.94

Polar Residues 11

number

3

A

5

R

2

N

1

D

0

C

4

E

1

Q

0

G

1

H

1

I

4

L

1

K

0

M

0

F

4

P

2

S

1

T

0

W

5

Y

1

V

Amino Acid Distribution

A: 3 R: 5 N: 2 D: 1 C: 0 E: 4 Q: 1 G: 0 H: 1 I: 1 L: 4 K: 1 M: 0 F: 0 P: 4 S: 2 T: 1 W: 0 Y: 5 V: 1

Length

36

Formula

C198H303N57O58

Mass

4409.93

PI

9.26

Net Charge

+1

Boman Index

11.24

Hydrophobicity

-1.208

Evidence 1 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Neuropeptide Y receptor type 1 Neuropeptide Y receptor type 2 Neuropeptide Y receptor type 4 Neuropeptide Y receptor type 5 Putative neuropeptide Y receptor type 6 Neuropeptide Y receptor type 4-2

Receptor Organisms Homo sapiens Homo sapiens Homo sapiens Homo sapiens Homo sapiens Homo sapiens

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Homo sapiens

Family NPY

Receptor Lengths 384 381 375 445 290 375

Receptor Ligands NP07551 NP07607 NP07652 NP07689 NP07695 NP07718 NP07719 NP07720 NP07551 NP07607 NP07652 NP07689 NP07695 NP07718 NP07719 NP07720 NP07551 NP07607 NP07652 NP07689 NP07695 NP07718 NP07719 NP07720 NP07551 NP07607 NP07652 NP07689 NP07695 NP07718 NP07719 NP07720 NP07551 NP07607 NP07652 NP07689 NP07695 NP07718 NP07719 NP07720 NP07551 NP07607 NP07652 NP07689 NP07695 NP07718 NP07719 NP07720

Evidence 2 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

- | NA | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Broad spectrum antibiotic activity of the skin-PYY. | FEBS Lett | 1996

Evidence 3 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

- | NA | target cell: Murine macrophages

Target

Target Cell Murine macrophages

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Broad spectrum antibiotic activity of the skin-PYY. | FEBS Lett | 1996

Family

NPY

Receptor_Lengths

384 381 375 445 290

Receptor_Ligands

NP07551 NP07607 NP07652 NP07689 NP07695 NP07718 NP07719 NP07720