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Peptide record

TPDB27420

Antibacterial Antifungal Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB27420
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, Antifungipept, CAFPdb, and other sources, with an available 3D structural model.
Sequence
YGRKKRRQRRRD
Physicochemical Analysis
C68H123N33O17
ANCEHILMFPSTWV
R
1674.94
12.41
8
1
1
+7
7.72
-3.625
0.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
88.96
2
Residue Composition
number
0
A
6
R
0
N
1
D
0
C
0
E
1
Q
1
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
12
C68H123N33O17
1674.94
12.41
+7
7.72
-3.625
Evidence Records 3 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against MRSA demonstrated in human HeLa cells in vitro. D-form is more effective due to resistance to proteases (D>L). A similar sequence TAT(48-57) (seq: GRKKRRQRRR) inhibits HIV-1 ( Keogan et al., 2012 ).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against MRSA demonstrated in human HeLa cells in vitro. D-form is more effective due to resistance to proteases (D>L). A similar sequence TAT(48-57) (seq: GRKKRRQRRR) inhibits HIV-1 ( Keogan et al., 2012 ).
Evidence 3 Activity

Activity

0% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
0% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Biological activity of Tat (47-58) peptide on human pathogenic fungi | Biochem Biophys Res Commun | 2006