Back to search

Peptide record

TPDB27412

Big dynorphin Antibacterial Neuropeptide standard
32 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB27412
Big dynorphin
Antibacterial Neuropeptide
Anti-infective peptides Neuroactive peptides
Peptipedia
standard
No
A 32-aa standard natural multi-activity (Antibacterial and Neuropeptide) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
YGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVT
Physicochemical Analysis
C185H292N58O41
ACEHMS
R
3984.72
12.13
10
1
12
+9
3.29
-0.978
66.88
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
8480
212.81
6
Residue Composition
number
0
A
6
R
1
N
1
D
0
C
0
E
2
Q
4
G
0
H
1
I
3
L
4
K
0
M
3
F
1
P
0
S
1
T
1
W
2
Y
2
V
Amino Acid Distribution
A: 0 R: 6 N: 1 D: 1 C: 0 E: 0 Q: 2 G: 4 H: 0 I: 1 L: 3 K: 4 M: 0 F: 3 P: 1 S: 0 T: 1 W: 1 Y: 2 V: 2
Chemical Descriptors
32
C185H292N58O41
3984.72
12.13
+9
3.29
-0.978
Evidence Records 14 records
Evidence 1 Activity

Activity

MIC
Antibacterial
25 µM

Target

Escherichia coli ATCC11775

Source & Reference

NA

Other

Active against E. coli ATCC11775 (MIC 25 uM), P. aeruginosa PA01 (MIC 25 uM), P. aeruginosa PA14 (MIC 12.5 uM), S. aureus ATCC12600 (M
Evidence 2 Activity

Activity

MIC
Antibacterial
25 µM

Target

Pseudomonas aeruginosa PA01

Source & Reference

NA

Other

Active against E. coli ATCC11775 (MIC 25 uM), P. aeruginosa PA01 (MIC 25 uM), P. aeruginosa PA14 (MIC 12.5 uM), S. aureus ATCC12600 (MIC 3.12 uM), K-pneumoniae ATCC13
Evidence 3 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Pseudomonas aeruginosa PA14

Source & Reference

NA

Other

Active against E. coli ATCC11775 (MIC 25 uM), P. aeruginosa PA01 (MIC 25 uM), P. aeruginosa PA14 (MIC 12.5 uM), S. aureus ATCC12600 (MIC 3.12 uM), K-pneumoniae ATCC133883 (MIC >50 uM), A-baumannii ATC
Evidence 4 Activity

Activity

MIC
Antibacterial
3.12 µM

Target

Staphylococcus aureus ATCC12600

Source & Reference

NA

Other

ATCC11775 (MIC 25 uM), P. aeruginosa PA01 (MIC 25 uM), P. aeruginosa PA14 (MIC 12.5 uM), S. aureus ATCC12600 (MIC 3.12 uM), K-pneumoniae ATCC133883 (MIC >50 uM), A-baumannii ATCC19606 (MIC >50 uM), A. muciniphila
Evidence 5 Activity

Activity

MIC
Antibacterial
50 µM

Target

A. muciniphila ATCC BAA-835

Source & Reference

NA

Other

(MIC 3.12 uM), K-pneumoniae ATCC133883 (MIC >50 uM), A-baumannii ATCC19606 (MIC >50 uM), A. muciniphila ATCC BAA-835 (MIC 50 uM), B-fragilis ATCC25285 (MIC >50 uM), B. vulgatus ATCC8482 (MIC 12.5 uM), C. aerofaciens AT
Evidence 6 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Bacteroides vulgatus ATCC8482

Source & Reference

NA

Other

(MIC >50 uM), A. muciniphila ATCC BAA-835 (MIC 50 uM), B-fragilis ATCC25285 (MIC >50 uM), B. vulgatus ATCC8482 (MIC 12.5 uM), C. aerofaciens ATCC25986 (MIC 12.5 uM), C. scindens ATCC35704 (MIC 3.12 uM), B-thetaiota
Evidence 7 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

C. aerofaciens ATCC25986

Source & Reference

NA

Other

A-835 (MIC 50 uM), B-fragilis ATCC25285 (MIC >50 uM), B. vulgatus ATCC8482 (MIC 12.5 uM), C. aerofaciens ATCC25986 (MIC 12.5 uM), C. scindens ATCC35704 (MIC 3.12 uM), B-thetaiotaomicron ATCC29148 (MIC >50 uM), B-unifor
Evidence 8 Activity

Activity

MIC
Antibacterial
3.12 µM

Target

C. scindens ATCC35704

Source & Reference

NA

Other

(MIC >50 uM), B. vulgatus ATCC8482 (MIC 12.5 uM), C. aerofaciens ATCC25986 (MIC 12.5 uM), C. scindens ATCC35704 (MIC 3.12 uM), B-thetaiotaomicron ATCC29148 (MIC >50 uM), B-uniformis ATCC8492 (MIC >50 uM), B-eggerthi
Evidence 9 Activity

Activity

Neuropeptide

Target

Kappa-type opioid receptor
Bos taurus

Source & Reference

NA
NeuroPepV2

Other

Bos taurus
Opioid
380
NP08044 NP07971 NP08003 NP08009 NP08025 NP08032 NP08038 NP07979
Evidence 10 Activity

Activity

Neuropeptide

Target

Kappa-type opioid receptor
Cavia porcellus

Source & Reference

NA
NeuroPepV2

Other

Cavia porcellus
Opioid
380
NP07972 NP08004 NP08010 NP08026 NP08033 NP08039 NP07981
Evidence 11 Activity

Activity

Neuropeptide

Target

Delta-type opioid receptor Kappa-type opioid receptor
Homo sapiens Homo sapiens

Source & Reference

NA
NeuroPepV2

Other

Homo sapiens
Opioid
372 380
NP08081 NP08163 NP08168 NP08174 NP08239 NP07973 NP08005 NP08011 NP08027 NP08034 NP08040 NP08114 NP08068 NP08075 NP08123 NP08130 NP08247 NP08092 NP07973 NP08005 NP08011 NP08027 NP08034 NP08040 NP07982
Evidence 12 Activity

Activity

Neuropeptide

Target

Kappa-type opioid receptor
Mus musculus

Source & Reference

NA
NeuroPepV2

Other

Mus musculus
Opioid
380
NP07974 NP08006 NP08012 NP08028 NP08035 NP08041 NP07999 NP07987
Evidence 13 Activity

Activity

Neuropeptide

Source & Reference

NA
NeuroPepV2

Other

Sus scrofa
Opioid
Evidence 14 Activity

Activity

Neuropeptide

Target

Delta-type opioid receptor Kappa-type opioid receptor
Rattus norvegicus Rattus norvegicus

Source & Reference

NA
NeuroPepV2

Other

Rattus norvegicus
Opioid
372 380
NP07976 NP08008 NP08014 NP08030 NP08037 NP08043 NP08071 NP08084 NP08242 NP08117 NP08125 NP08133 NP08166 NP08172 NP08178 NP08250 NP08078 NP07992 NP08102 NP07976 NP08008 NP08014 NP08030 NP08037 NP08043 NP07992
Additional Detail Fields 3 fields
Opioid
380 372
NP08044 NP07971 NP08003 NP08009 NP08025 NP08032 NP08038 NP07979 NP07972 NP08004 NP08010 NP08026 NP08033 NP08039 NP07981 NP08081 NP08163 NP08168 NP08174 NP08239 NP07973 NP08005 NP08011 NP08027 NP08034 NP08040 NP08114 NP08068 NP08075 NP08123 NP08130 NP08247 NP08092 NP07982 NP07974 NP08006 NP08012 NP08028 NP08035 NP08041 NP07999 NP07987 NP07976 NP08008 NP08014 NP08030 NP08037 NP08043 NP08071 NP08084 NP08242 NP08117 NP08125 NP08133 NP08166 NP08172 NP08178 NP08250 NP08078 NP07992 NP08102