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Peptide record

TPDB27404

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) YF dipeptide Antibacterial Anticancer Antihypertensive Bitter Toxicity iDPPIV Selfassembly standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB27404
dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) YF dipeptide
Antibacterial Anticancer Antihypertensive Bitter Toxicity iDPPIV Selfassembly
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Toxicity and safety peptides Food sensory peptides Self-assembling and biomaterial peptides
Peptipedia AHTPDB Tastepeptides-Meta iDPPIV SAPdb
standard
No
A 2-aa standard natural multi-activity (Antibacterial, Anticancer, Antihypertensive, and other sources) peptide sequence curated from Peptipedia, AHTPDB, Tastepeptides-Meta, and other sources, with an available 3D structural model.
Sequence
YF
Physicochemical Analysis
C18H20N2O4
ARNDCEQGHILKMPSTWV
FY
328.37
5.94
0
0
2
-0
-2.07
0.750
0.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
453.76
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
2
C18H20N2O4
328.37
5.94
-0
-2.07
0.750
328.3616
328.1418
Self-Assembly Information 2 records
Record 1 Selfassembly

Source

24999600
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Microribbon
temperature: 27 °C solvent: HFIP (1,1,1,3,3,3-hexafluoro-2-Isopropanol) concentration: 1 mg/ml
Selfassembly; Nanostructure=Microribbon; Trigger=temperature: 27 °C; solvent: HFIP (1,1,1,3,3,3-hexafluoro-2-Isopropanol); concentration: 1 mg/ml
Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM)
Selfassembly
Record 2 Selfassembly

Source

24999600
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Microsphere
temperature: 27 °C solvent: TFE (2,2,2-trifluoroethanol) concentration: 1 mg/ml
Selfassembly; Nanostructure=Microsphere; Trigger=temperature: 27 °C; solvent: TFE (2,2,2-trifluoroethanol); concentration: 1 mg/ml
Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM)
Selfassembly
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.
Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73, 2015
2015
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)O InChI=1S/C18H20N2O4/c19-15(10-13-6-8-14(21)9-7-13)17(22)20-16(18(23)24)11-12-4-2-1-3-5-12/h1-9,15-16,21H,10-11,19H2,(H,20,22)(H,23,24)/t15-,16-/m0/s1 InChIKey=CGWAPUBOXJWXMS-HOTGVXAUSA-N Inhibitor of Dipeptidyl peptidase III (DPP-III) (EC 3.4.14.4) (MEROPS ID: M49.003) according to the BIOPEP-UWM database of bioactive peptides (ID:9480) Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database the BioPepDB database (ID: 01554) Prolactin releasing peptide according to the EROP-Moscow database Herbicidal peptide according to the ChEMBL database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID: 54) Information concerning Dipeptidyl peptidase IV (DPP IV) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: S09.003)
Evidence 2 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Microribbon Trigger=temperature: 27 °C solvent: HFIP (1,1,1,3,3,3-hexafluoro-2-Isopropanol) concentration: 1 mg/ml
Microribbon

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: 27 °C solvent: HFIP (1,1,1,3,3,3-hexafluoro-2-Isopropanol) concentration: 1 mg/ml
Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM)
24999600
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID 1402 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row.
Evidence 3 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Microsphere Trigger=temperature: 27 °C solvent: TFE (2,2,2-trifluoroethanol) concentration: 1 mg/ml
Microsphere

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: 27 °C solvent: TFE (2,2,2-trifluoroethanol) concentration: 1 mg/ml
Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM)
24999600
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID 1403 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row.
Additional Detail Fields 6 fields
temperature: 27 °C solvent: HFIP (1,1,1,3,3,3-hexafluoro-2-Isopropanol) concentration: 1 mg/ml solvent: TFE (2,2,2-trifluoroethanol)
None specified
SAPdb ID 1402 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row. SAPdb ID 1403
2
24999600
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly