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Peptide record

TPDB27388

Antibacterial Toxicity modified_plain modified
15 amino acids
Basic Information
3D PDB MODEL
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TPDB27388
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 15-aa modified multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
WLKKLKKXLKKLXKK
Physicochemical Analysis
C83H152N22O14
ARNDCEQGHIMFPSTYV
K
1682.26
11.36
8
0
5
+8
3.83
-1.127
104.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
326.94
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
4
L
8
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 4 K: 8 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
15
C83H152N22O14
1682.26
11.36
+8
3.83
-1.127
Evidence Records 12 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
0% Hemolysis | 128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Designing double-site lipidated peptide amphiphiles as potent antimicrobial biomaterials to combat multidrug-resistant bacteria. | Front Microbiol | 2022
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Designing double-site lipidated peptide amphiphiles as potent antimicrobial biomaterials to combat multidrug-resistant bacteria. | Front Microbiol | 2022
Evidence 3 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Intestinal Porcine Epithelial Cells IPEC-J2

Target

Intestinal Porcine Epithelial Cells IPEC-J2

Source & Reference

NA
DBAASP
Designing double-site lipidated peptide amphiphiles as potent antimicrobial biomaterials to combat multidrug-resistant bacteria. | Front Microbiol | 2022
Evidence 4 Activity

Activity

15% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
15% Hemolysis | 128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Designing double-site lipidated peptide amphiphiles as potent antimicrobial biomaterials to combat multidrug-resistant bacteria. | Front Microbiol | 2022
Evidence 5 Activity

Activity

45% Cytotoxicity
Toxicity
64 µM
Cytotoxic
45% Cytotoxicity | 64 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Designing double-site lipidated peptide amphiphiles as potent antimicrobial biomaterials to combat multidrug-resistant bacteria. | Front Microbiol | 2022
Evidence 6 Activity

Activity

10% Hemolysis
Toxicity
8 µM
Hemolytic Cytotoxic
10% Hemolysis | 8 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Designing double-site lipidated peptide amphiphiles as potent antimicrobial biomaterials to combat multidrug-resistant bacteria. | Front Microbiol | 2022
Evidence 7 Activity

Activity

20% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
20% Hemolysis | 128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Designing double-site lipidated peptide amphiphiles as potent antimicrobial biomaterials to combat multidrug-resistant bacteria. | Front Microbiol | 2022
Evidence 8 Activity

Activity

70% Cytotoxicity
Toxicity
64 µM
Cytotoxic
70% Cytotoxicity | 64 | µM | target cell: Intestinal Porcine Epithelial Cells IPEC-J2

Target

Intestinal Porcine Epithelial Cells IPEC-J2

Source & Reference

NA
DBAASP
Designing double-site lipidated peptide amphiphiles as potent antimicrobial biomaterials to combat multidrug-resistant bacteria. | Front Microbiol | 2022
Evidence 9 Activity

Activity

97% Cytotoxicity
Toxicity
64 µM
Cytotoxic
97% Cytotoxicity | 64 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Designing double-site lipidated peptide amphiphiles as potent antimicrobial biomaterials to combat multidrug-resistant bacteria. | Front Microbiol | 2022
Evidence 10 Activity

Activity

14% Hemolysis
Toxicity
8 µM
Hemolytic Cytotoxic
14% Hemolysis | 8 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Designing double-site lipidated peptide amphiphiles as potent antimicrobial biomaterials to combat multidrug-resistant bacteria. | Front Microbiol | 2022
Evidence 11 Activity

Activity

40% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
40% Hemolysis | 128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Designing double-site lipidated peptide amphiphiles as potent antimicrobial biomaterials to combat multidrug-resistant bacteria. | Front Microbiol | 2022
Evidence 12 Activity

Activity

65% Cytotoxicity
Toxicity
64 µM
Cytotoxic
65% Cytotoxicity | 64 | µM | target cell: Intestinal Porcine Epithelial Cells IPEC-J2

Target

Intestinal Porcine Epithelial Cells IPEC-J2

Source & Reference

NA
DBAASP
Designing double-site lipidated peptide amphiphiles as potent antimicrobial biomaterials to combat multidrug-resistant bacteria. | Front Microbiol | 2022