Back to search

Peptide record

TPDB27327

Antibacterial Toxicity modified_plain modified
10 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB27327
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 10-aa modified multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
XGLXGKLXGI
Physicochemical Analysis
C30H56N8O8
ARNDCEQHMFPSTWYV
G
656.82
10.10
1
0
3
+1
-0.41
0.700
117.00
Mammalian: Yeast: E.coli:
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
1
I
2
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 1 L: 2 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C30H56N8O8
656.82
10.10
+1
-0.41
0.700
Evidence Records 4 records
Evidence 1 Activity

Activity

20% Hemolysis
Toxicity
8 µM
Hemolytic Cytotoxic
20% Hemolysis | 8 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The peculiar N- and (-termini of trichogin GA IV are needed for membrane interaction and human cell death induction at doses lacking antibiotic activity. | Biochim Biophys Acta | 2015
Evidence 2 Activity

Activity

65% Hemolysis
Toxicity
16 µM
Hemolytic Cytotoxic
65% Hemolysis | 16 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The peculiar N- and (-termini of trichogin GA IV are needed for membrane interaction and human cell death induction at doses lacking antibiotic activity. | Biochim Biophys Acta | 2015
Evidence 3 Activity

Activity

50% Cell death
Toxicity
2 µM
Cytotoxic
50% Cell death | 2 | µM | target cell: Human dermal fibroblasts

Target

Human dermal fibroblasts

Source & Reference

NA
DBAASP
The rational search for selective anticancer derivatives of the peptide Trichogin GA IV: a multi-technique biophysical approach. | Sci Rep | 2016
Evidence 4 Activity

Activity

50% Cell death
Toxicity
5 µM
Cytotoxic
50% Cell death | 5 | µM | target cell: Human dermal fibroblasts

Target

Human dermal fibroblasts

Source & Reference

NA
DBAASP
The rational search for selective anticancer derivatives of the peptide Trichogin GA IV: a multi-technique biophysical approach. | Sci Rep | 2016