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Peptide record

TPDB27291

Antibacterial Anticancer Antifungal Toxicity modified_plain modified
8 amino acids
Basic Information
3D PDB MODEL
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TPDB27291
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
modified_plain
Yes
A 8-aa modified multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Modified, details unspecified
Sequence
XFFLSRIF
Physicochemical Analysis
C48H68N10O9
ANDCEQGHKMPTWYV
F
929.13
11.05
1
0
5
+1
-3.32
1.425
97.50
Mammalian: Yeast: E.coli:
0
0.00
1
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
1
L
0
K
0
M
3
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 0 M: 0 F: 3 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
8
C48H68N10O9
929.13
11.05
+1
-3.32
1.425
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>200 µM
Hemolytic Cytotoxic
50% Hemolysis | >200 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Structure-Activity Relationship-based Optimization of Small Temporin-SHf Analogs with Potent Antibacterial Activity | ACS Chem Biol | 2015
Evidence 2 Activity

Activity

IC50
Toxicity
71 µM
Cytotoxic
IC50 | 71 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Structure-Activity Relationship-based Optimization of Small Temporin-SHf Analogs with Potent Antibacterial Activity | ACS Chem Biol | 2015
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
ACS Chem Biol. 2015 Oct 16 10(10):2257-66.