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Peptide record

TPDB27269

Antibacterial Anticancer Antifungal Antiparasitic Toxicity modified_plain modified
18 amino acids
Basic Information
3D PDB MODEL
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TPDB27269
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP dbAMP 3.0
modified_plain
Yes
A 18-aa modified multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Modified, details unspecified
Sequence
XCRRLCYKQRCVTYCRGR
Physicochemical Analysis
C88H150N34O22S4
ANDEHIMFPSW
R
2164.61
10.10
6
0
4
+6
2.44
-0.867
37.78
Mammalian: Yeast: E.coli:
3230
149.22
8
Residue Composition
number
0
A
5
R
0
N
0
D
4
C
0
E
1
Q
1
G
0
H
0
I
1
L
1
K
0
M
0
F
0
P
0
S
1
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 4 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 2 V: 1
Chemical Descriptors
18
C88H150N34O22S4
2164.61
10.10
+6
2.44
-0.867
Evidence Records 9 records
Evidence 1 Activity

Activity

4.4±0.1% Hemolysis
Toxicity
300 µg/mL
Hemolytic Cytotoxic
4.4±0.1% Hemolysis | 300 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Contribution of Amphipathicity and Hydrophobicity to the Antimicrobial Activity and Cytotoxicity of β-Hairpin Peptides. | ACS Infect Dis | 2016
Evidence 2 Activity

Activity

50% Cell death
Toxicity
49.9±16.6 µM
Cytotoxic
50% Cell death | 49.9±16.6 | µM | target cell: Human foreskin fibroblasts (HFF)

Target

Human foreskin fibroblasts (HFF)

Source & Reference

NA
DBAASP
Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. | ACS Chem Biol | 2017
Evidence 3 Activity

Activity

47.2±6.0% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
47.2±6.0% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. | ACS Chem Biol | 2017
Evidence 4 Activity

Activity

50% Cell death
Toxicity
13.4±1.8 µM
Cytotoxic
50% Cell death | 13.4±1.8 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. | ACS Chem Biol | 2017
Evidence 5 Activity

Activity

50% Cell death
Toxicity
75 µg/mL
Cytotoxic
50% Cell death | 75 | µg/mL | target cell: Human neonatal skin fbroblasts NFF

Target

Human neonatal skin fbroblasts NFF

Source & Reference

NA
DBAASP
Gomesin inhibits melanoma growth by manipulating key signaling cascades that control cell death and proliferation. | Sci Rep | 2018
Evidence 6 Activity

Activity

18% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
18% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Gomesin inhibits melanoma growth by manipulating key signaling cascades that control cell death and proliferation. | Sci Rep | 2018
Evidence 7 Activity

Activity

16% Hemolysis
Toxicity
1 µM
Hemolytic Cytotoxic
16% Hemolysis | 1 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 8 Activity

Activity

CC50
Toxicity
58.2±3.0 µM
Cytotoxic
CC50 | 58.2±3.0 | µM | target cell: Human foreskin fibroblasts (HFF)

Target

Human foreskin fibroblasts (HFF)

Source & Reference

NA
DBAASP
Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. | ACS Chem Biol | 2017
Evidence 9 Activity

Activity

30.7±8.1% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
30.7±8.1% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. | ACS Chem Biol | 2017