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Peptide record

TPDB27242

Antibacterial Anticancer Toxicity modified_plain modified
6 amino acids
Basic Information
3D PDB MODEL
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TPDB27242
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 6-aa modified multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
XXXXXX
Physicochemical Analysis
ARNDCEQGHILKMFPSTWYV
18.02
6.02
0
0
0
-0
0.00
0.000
0.00
Mammalian: Yeast: E.coli:
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
6
18.02
6.02
-0
0.00
0.000
Evidence Records 16 records
Evidence 1 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human gingival fibroblasts

Target

Human gingival fibroblasts

Source & Reference

NA
DBAASP
Self-Assembly of Antimicrobial Peptoids Impacts Their Biological Effects on ESKAPE Bacterial Pathogens. | ACS Infect Dis | 2022
Evidence 2 Activity

Activity

IC50
Toxicity
146.9 µg/mL
Cytotoxic
IC50 | 146.9 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Halogenation as a tool to tune antimicrobial activity of peptoids | Sci Rep | 2020
Evidence 3 Activity

Activity

IC50
Toxicity
250 µg/mL
Cytotoxic
IC50 | 250 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Halogenation as a tool to tune antimicrobial activity of peptoids | Sci Rep | 2020
Evidence 4 Activity

Activity

IC50
Toxicity
632.4 µg/mL
Cytotoxic
IC50 | 632.4 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Halogenation as a tool to tune antimicrobial activity of peptoids | Sci Rep | 2020
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
>250 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cyclization Improves Membrane Permeation by Antimicrobial Peptoids | Langmuir | 2016
Evidence 6 Activity

Activity

10% Hemolysis
Toxicity
>62.5 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | >62.5 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A comparison of linear and cyclic peptoid oligomers as potent antimicrobial agents | ChemMedChem | 2012
Evidence 7 Activity

Activity

10% Hemolysis
Toxicity
31.3 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 31.3 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A comparison of linear and cyclic peptoid oligomers as potent antimicrobial agents | ChemMedChem | 2012
Evidence 8 Activity

Activity

10% Hemolysis
Toxicity
>250 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | >250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A comparison of linear and cyclic peptoid oligomers as potent antimicrobial agents | ChemMedChem | 2012
Evidence 9 Activity

Activity

10% Hemolysis
Toxicity
23.6 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 23.6 | µg/mL | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of peptoids against Metallo-β-lactamase-producing Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and other WHO priority pathogens, including Candida auris. | J Appl Microbiol | 2025
Evidence 10 Activity

Activity

50% Hemolysis
Toxicity
86.4 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 86.4 | µg/mL | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of peptoids against Metallo-β-lactamase-producing Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and other WHO priority pathogens, including Candida auris. | J Appl Microbiol | 2025
Evidence 11 Activity

Activity

10% Hemolysis
Toxicity
8 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 8 | µg/mL | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of peptoids against Metallo-β-lactamase-producing Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and other WHO priority pathogens, including Candida auris. | J Appl Microbiol | 2025
Evidence 12 Activity

Activity

50% Hemolysis
Toxicity
20.8 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 20.8 | µg/mL | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of peptoids against Metallo-β-lactamase-producing Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and other WHO priority pathogens, including Candida auris. | J Appl Microbiol | 2025
Evidence 13 Activity

Activity

50% Hemolysis
Toxicity
>250 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A comparison of linear and cyclic peptoid oligomers as potent antimicrobial agents | ChemMedChem | 2012
Evidence 14 Activity

Activity

IC50
Toxicity
92.6 µg/mL
Cytotoxic
IC50 | 92.6 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Halogenation as a tool to tune antimicrobial activity of peptoids | Sci Rep | 2020
Evidence 15 Activity

Activity

10% Hemolysis
Toxicity
125 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 125 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Amphiphilic Cyclic Peptoids That Exhibit Antimicrobial Activity by Disrupting Staphylococcus aureus Membranes | Eur J Org Chem | 2013
Evidence 16 Activity

Activity

10% Hemolysis
Toxicity
31.3 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 31.3 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Amphiphilic Cyclic Peptoids That Exhibit Antimicrobial Activity by Disrupting Staphylococcus aureus Membranes | Eur J Org Chem | 2013