TPDB27212

Evidence 1 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 33 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 33 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Short alkylated peptoid mimics of antimicrobial lipopeptides. | Antimicrob Agents Chemother | 2011

Evidence 2 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 145 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 145 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Short alkylated peptoid mimics of antimicrobial lipopeptides. | Antimicrob Agents Chemother | 2011

Evidence 3 Activity

Activity

Activity Endpoint 50% Cell death

Detail Source Activity Toxicity

Activity Measurement 12 µM

Toxicity Type Cytotoxic

Toxicity Raw

50% Cell death | 12 | µM | target cell: Murine macrophage cells J774A.1

Target

Target Cell Murine macrophage cells J774A.1

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Efficacy of antimicrobial peptoids against Mycobacterium tuberculosis. | Antimicrob Agents Chemother | 2011

Evidence 4 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 35.0 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 35.0 | µg/mL | target cell: Human keratinocytes HaCat

Target

Target Cell Human keratinocytes HaCat

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Halogenation as a tool to tune antimicrobial activity of peptoids | Sci Rep | 2020

Evidence 5 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Toxicity

Activity Measurement 8 µM

Toxicity Type Cytotoxic

Toxicity Raw

LC50 | 8 | µM | target cell: Human fibroblasts MRC-5

Target

Target Cell Human fibroblasts MRC-5

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity | PLoS One | 2014

Evidence 6 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Toxicity

Activity Measurement 8 µM

Toxicity Type Cytotoxic

Toxicity Raw

LC50 | 8 | µM | target cell: Human dermal fibroblasts

Target

Target Cell Human dermal fibroblasts

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity | PLoS One | 2014

Evidence 7 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 21 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 21 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity | PLoS One | 2014

Evidence 8 Activity

Activity

Activity Endpoint 9% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 150 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

9% Hemolysis | 150 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Lysine-Based α-Peptide/β-Peptoid Peptidomimetics: Influence of Hydrophobicity, Fluorination, and Distribution of Cationic Charge on Antimicrobial Activity and Cytotoxicity | ChemMedChem | 2017

Evidence 9 Activity

Activity

Activity Endpoint 5% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 150 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

5% Hemolysis | 150 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Lysine-Based α-Peptide/β-Peptoid Peptidomimetics: Influence of Hydrophobicity, Fluorination, and Distribution of Cationic Charge on Antimicrobial Activity and Cytotoxicity | ChemMedChem | 2017

Evidence 10 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 25 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 25 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antimicrobial, hemolytic, and cytotoxic activities of beta-peptoid-peptide hybrid oligomers: improved properties compared to natural AMPs. | Chembiochem | 2010

Evidence 11 Activity

Activity

Activity Endpoint 98.4% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 400 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

98.4% Hemolysis | 400 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Peptide/β-Peptoid Hybrids with Activity against Vancomycin-Resistant Enterococci: Influence of Hydrophobicity and Structural Features on Antibacterial and Hemolytic Properties. | Int J Mol Sci | 2021

Evidence 12 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >200 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | >200 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 13 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >200 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | >200 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 14 Activity

Activity

Activity Endpoint 9.2±0.4% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 200 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

9.2±0.4% Hemolysis | 200 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 15 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Toxicity

Activity Measurement 30 µM

Toxicity Type Cytotoxic

Toxicity Raw

LC50 | 30 | µM | target cell: Human fibroblasts MRC-5

Target

Target Cell Human fibroblasts MRC-5

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity | PLoS One | 2014

Evidence 16 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Toxicity

Activity Measurement 39 µM

Toxicity Type Cytotoxic

Toxicity Raw

LC50 | 39 | µM | target cell: Human dermal fibroblasts

Target

Target Cell Human dermal fibroblasts

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity | PLoS One | 2014

Evidence 17 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 183 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 183 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity | PLoS One | 2014

Evidence 18 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 112.7 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 112.7 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 19 Activity

Activity

Activity Endpoint 31.0±5.3% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 200 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

31.0±5.3% Hemolysis | 200 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 20 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Toxicity

Activity Measurement 22 µM

Toxicity Type Cytotoxic

Toxicity Raw

LC50 | 22 | µM | target cell: Human fibroblasts MRC-5

Target

Target Cell Human fibroblasts MRC-5

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity | PLoS One | 2014

Evidence 21 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Toxicity

Activity Measurement 36 µM

Toxicity Type Cytotoxic

Toxicity Raw

LC50 | 36 | µM | target cell: Human dermal fibroblasts

Target

Target Cell Human dermal fibroblasts

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity | PLoS One | 2014

Evidence 22 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 160 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 160 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity | PLoS One | 2014

Evidence 23 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 89.6 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 89.6 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 24 Activity

Activity

Activity Endpoint 32.9±0.5% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 200 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

32.9±0.5% Hemolysis | 200 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 25 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 40 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 40 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 26 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 158.7 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 158.7 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 27 Activity

Activity

Activity Endpoint 66.5±3.6% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 200 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

66.5±3.6% Hemolysis | 200 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Evidence 28 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 52.8 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 52.8 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 29 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 169.1 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 169.1 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 30 Activity

Activity

Activity Endpoint 63.8±3.1% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 200 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

63.8±3.1% Hemolysis | 200 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 31 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 49.9 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 49.9 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 32 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 186.4 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 186.4 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 33 Activity

Activity

Activity Endpoint 53.9±6.4% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 200 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

53.9±6.4% Hemolysis | 200 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 34 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 74.7 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 74.7 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 35 Activity

Activity

Activity Endpoint 48.3±0.2% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 200 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

48.3±0.2% Hemolysis | 200 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 36 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 53.3 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 53.3 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 37 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 193.4 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 193.4 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 38 Activity

Activity

Activity Endpoint 52.1±5.2% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 200 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

52.1±5.2% Hemolysis | 200 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 39 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 92.4 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 92.4 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 40 Activity

Activity

Activity Endpoint 32.0±1.5% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 200 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

32.0±1.5% Hemolysis | 200 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 41 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 79.7 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 79.7 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 42 Activity

Activity

Activity Endpoint 43.4±2.7% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 200 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

43.4±2.7% Hemolysis | 200 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 43 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Toxicity

Activity Measurement 21 µM

Toxicity Type Cytotoxic

Toxicity Raw

LC50 | 21 | µM | target cell: Human fibroblasts MRC-5

Target

Target Cell Human fibroblasts MRC-5

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity | PLoS One | 2014

Evidence 44 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Toxicity

Activity Measurement 32 µM

Toxicity Type Cytotoxic

Toxicity Raw

LC50 | 32 | µM | target cell: Human dermal fibroblasts

Target

Target Cell Human dermal fibroblasts

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity | PLoS One | 2014

Evidence 45 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 120.3 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 120.3 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 46 Activity

Activity

Activity Endpoint 30.8±2.5% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 200 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

30.8±2.5% Hemolysis | 200 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 47 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 81.7 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 81.7 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 48 Activity

Activity

Activity Endpoint 16.0±5.1% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 200 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

16.0±5.1% Hemolysis | 200 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 49 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 53.9 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 53.9 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 50 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 199.6 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 199.6 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 51 Activity

Activity

Activity Endpoint 51.4±3.3% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 200 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

51.4±3.3% Hemolysis | 200 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 52 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 26.8 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 26.8 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 53 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 155.8 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 155.8 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 54 Activity

Activity

Activity Endpoint 61.4±4.5% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 200 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

61.4±4.5% Hemolysis | 200 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 55 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 61.6 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 61.6 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 56 Activity

Activity

Activity Endpoint 46.4±1.7% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 200 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

46.4±1.7% Hemolysis | 200 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 57 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 53.0 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 53.0 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 58 Activity

Activity

Activity Endpoint 47.2±2.3% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 200 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

47.2±2.3% Hemolysis | 200 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids | ACS Infect Dis | 2020

Evidence 59 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement <6.25 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | <6.25 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Effect of side chain hydrophobicity and cationic charge on antimicrobial activity and cytotoxicity of helical peptoids | Bioorg Med Chem Lett | 2018

Evidence 60 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 10.4 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 10.4 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Effect of side chain hydrophobicity and cationic charge on antimicrobial activity and cytotoxicity of helical peptoids | Bioorg Med Chem Lett | 2018

Evidence 61 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 3.0 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 3.0 | µM | target cell: Human fibroblasts MRC-5

Target

Target Cell Human fibroblasts MRC-5

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Effect of side chain hydrophobicity and cationic charge on antimicrobial activity and cytotoxicity of helical peptoids | Bioorg Med Chem Lett | 2018

Evidence 62 Activity

Activity

Activity Endpoint 100% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 200 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

100% Hemolysis | 200 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Evidence 63 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 8.3 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 8.3 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Effect of side chain hydrophobicity and cationic charge on antimicrobial activity and cytotoxicity of helical peptoids | Bioorg Med Chem Lett | 2018

Evidence 64 Activity

Activity

Activity Endpoint 100% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 200 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

100% Hemolysis | 200 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Effect of side chain hydrophobicity and cationic charge on antimicrobial activity and cytotoxicity of helical peptoids | Bioorg Med Chem Lett | 2018

Evidence 65 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 8.0 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 8.0 | µM | target cell: Human fibroblasts MRC-5

Target

Target Cell Human fibroblasts MRC-5

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Effect of side chain hydrophobicity and cationic charge on antimicrobial activity and cytotoxicity of helical peptoids | Bioorg Med Chem Lett | 2018

Evidence 66 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement <6.25 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | <6.25 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Effect of side chain hydrophobicity and cationic charge on antimicrobial activity and cytotoxicity of helical peptoids | Bioorg Med Chem Lett | 2018

Evidence 67 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 9.5 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 9.5 | µM | target cell: Human fibroblasts MRC-5

Target

Target Cell Human fibroblasts MRC-5

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Effect of side chain hydrophobicity and cationic charge on antimicrobial activity and cytotoxicity of helical peptoids | Bioorg Med Chem Lett | 2018

Evidence 68 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Toxicity

Activity Measurement 10 µM

Toxicity Type Cytotoxic

Toxicity Raw

LC50 | 10 | µM | target cell: Human fibroblasts MRC-5

Target

Target Cell Human fibroblasts MRC-5

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity | PLoS One | 2014

Evidence 69 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Toxicity

Activity Measurement 30 µM

Toxicity Type Cytotoxic

Toxicity Raw

LC50 | 30 | µM | target cell: Human dermal fibroblasts

Target

Target Cell Human dermal fibroblasts

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity | PLoS One | 2014

Evidence 70 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Toxicity

Activity Measurement 18 µM

Toxicity Type Cytotoxic

Toxicity Raw

LC50 | 18 | µM | target cell: Human fibroblasts MRC-5

Target

Target Cell Human fibroblasts MRC-5

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity | PLoS One | 2014

Evidence 71 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Toxicity

Activity Measurement 21 µM

Toxicity Type Cytotoxic

Toxicity Raw

LC50 | 21 | µM | target cell: Human dermal fibroblasts

Target

Target Cell Human dermal fibroblasts

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity | PLoS One | 2014

Evidence 72 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 80 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 80 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity | PLoS One | 2014

Evidence 73 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Toxicity

Activity Measurement 41 µM

Toxicity Type Cytotoxic

Toxicity Raw

LC50 | 41 | µM | target cell: Human fibroblasts MRC-5

Target

Target Cell Human fibroblasts MRC-5

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity | PLoS One | 2014

Evidence 74 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Toxicity

Activity Measurement 34 µM

Toxicity Type Cytotoxic

Toxicity Raw

LC50 | 34 | µM | target cell: Human dermal fibroblasts

Target

Target Cell Human dermal fibroblasts

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity | PLoS One | 2014

Evidence 75 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >100 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity | PLoS One | 2014

Evidence 76 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >200 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | >200 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

In Vivo, In Vitro, and In Silico Characterization of Peptoids as Antimicrobial Agents | PLoS One | 2016

Evidence 77 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 83 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 83 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Target Cell Mouse fibroblasts NIH 3T3

Source & Reference

Database Source NA

Source Database DBAASP

Reference

In Vivo, In Vitro, and In Silico Characterization of Peptoids as Antimicrobial Agents | PLoS One | 2016

Evidence 78 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 64 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

In Vivo, In Vitro, and In Silico Characterization of Peptoids as Antimicrobial Agents | PLoS One | 2016

Evidence 79 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >200 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | >200 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

In Vivo, In Vitro, and In Silico Characterization of Peptoids as Antimicrobial Agents | PLoS One | 2016

Evidence 80 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 8.5 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 8.5 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Target Cell Mouse fibroblasts NIH 3T3

Source & Reference

Database Source NA

Source Database DBAASP

Reference

In Vivo, In Vitro, and In Silico Characterization of Peptoids as Antimicrobial Agents | PLoS One | 2016