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Peptide record

TPDB27200

Antibacterial Anticancer Antifungal Toxicity modified_plain modified
5 amino acids
Basic Information
3D PDB MODEL
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TPDB27200
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
modified_plain
Yes
A 5-aa modified multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Modified, details unspecified
Sequence
XXXXX
Physicochemical Analysis
ARNDCEQGHILKMFPSTWYV
18.02
6.02
0
0
0
-0
0.00
0.000
0.00
Mammalian: Yeast: E.coli:
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
5
18.02
6.02
-0
0.00
0.000
Evidence Records 16 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
73 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 73 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Short alkylated peptoid mimics of antimicrobial lipopeptides. | Antimicrob Agents Chemother | 2011
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
224 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 224 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Short alkylated peptoid mimics of antimicrobial lipopeptides. | Antimicrob Agents Chemother | 2011
Evidence 3 Activity

Activity

10% Killing
Toxicity
45 µM
Cytotoxic
10% Killing | 45 | µM | target cell: Murine macrophage cells J774A.1

Target

Murine macrophage cells J774A.1

Source & Reference

NA
DBAASP
Efficacy of antimicrobial peptoids against Mycobacterium tuberculosis. | Antimicrob Agents Chemother | 2011
Evidence 4 Activity

Activity

50% Cell death
Toxicity
37.1 µg/mL
Cytotoxic
50% Cell death | 37.1 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Design, Synthesis, and Nanostructure-Dependent Antibacterial Activity of Cationic Peptide Amphiphiles. | ACS Appl Mater Interfaces | 2019
Evidence 5 Activity

Activity

50% Cell death
Toxicity
18.7 µg/mL
Cytotoxic
50% Cell death | 18.7 | µg/mL | target cell: Human Colon Epithelial Cells HCEC

Target

Human Colon Epithelial Cells HCEC

Source & Reference

NA
DBAASP
Design, Synthesis, and Nanostructure-Dependent Antibacterial Activity of Cationic Peptide Amphiphiles. | ACS Appl Mater Interfaces | 2019
Evidence 6 Activity

Activity

50% Cell death
Toxicity
20.3 µg/mL
Cytotoxic
50% Cell death | 20.3 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Design, Synthesis, and Nanostructure-Dependent Antibacterial Activity of Cationic Peptide Amphiphiles. | ACS Appl Mater Interfaces | 2019
Evidence 7 Activity

Activity

50% Hemolysis
Toxicity
16.1 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 16.1 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design, Synthesis, and Nanostructure-Dependent Antibacterial Activity of Cationic Peptide Amphiphiles. | ACS Appl Mater Interfaces | 2019
Evidence 8 Activity

Activity

50% Hemolysis
Toxicity
1000 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 1000 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Development of novel membrane active lipidated peptidomimetics active against drug resistant clinical isolates. | Bioorg Med Chem | 2014
Evidence 9 Activity

Activity

50% Hemolysis
Toxicity
750 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 750 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Development of novel membrane active lipidated peptidomimetics active against drug resistant clinical isolates. | Bioorg Med Chem | 2014
Evidence 10 Activity

Activity

50% Hemolysis
Toxicity
500 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 500 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Development of novel membrane active lipidated peptidomimetics active against drug resistant clinical isolates. | Bioorg Med Chem | 2014
Evidence 11 Activity

Activity

50% Hemolysis
Toxicity
350 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 350 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Development of novel membrane active lipidated peptidomimetics active against drug resistant clinical isolates. | Bioorg Med Chem | 2014
Evidence 12 Activity

Activity

50% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Development of novel membrane active lipidated peptidomimetics active against drug resistant clinical isolates. | Bioorg Med Chem | 2014
Evidence 13 Activity

Activity

50% Hemolysis
Toxicity
1000 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 1000 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Systematic study of non-natural short cationic lipopeptides as novel broad-spectrum antimicrobial agents. | Chem Biol Drug Des | 2013
Evidence 14 Activity

Activity

50% Hemolysis
Toxicity
750 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 750 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Systematic study of non-natural short cationic lipopeptides as novel broad-spectrum antimicrobial agents. | Chem Biol Drug Des | 2013
Evidence 15 Activity

Activity

50% Hemolysis
Toxicity
500 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 500 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Systematic study of non-natural short cationic lipopeptides as novel broad-spectrum antimicrobial agents. | Chem Biol Drug Des | 2013
Evidence 16 Activity

Activity

50% Hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Systematic study of non-natural short cationic lipopeptides as novel broad-spectrum antimicrobial agents. | Chem Biol Drug Des | 2013