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Peptide record

TPDB27197

Antibacterial Anticancer Toxicity modified_plain modified
7 amino acids
Basic Information
3D PDB MODEL
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TPDB27197
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 7-aa modified multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
XXXXKKK
Physicochemical Analysis
C18H38N6O4
ARNDCEQGHILMFPSTWYV
K
402.54
10.84
3
0
0
+3
2.97
-1.671
0.00
Mammalian: Yeast: E.coli:
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
3
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C18H38N6O4
402.54
10.84
+3
2.97
-1.671
Evidence Records 15 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
11.2 µM
Hemolytic Cytotoxic
10% Hemolysis | 11.2 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides | Sci Rep | 2020
Evidence 2 Activity

Activity

78.1% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
78.1% Hemolysis | 150 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides | Sci Rep | 2020
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
40.0 µM
Hemolytic Cytotoxic
50% Hemolysis | 40.0 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides | Sci Rep | 2020
Evidence 4 Activity

Activity

100% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
100% Hemolysis | 150 | µM | target cell: Dog erythrocytes

Target

Dog erythrocytes

Source & Reference

NA
DBAASP
Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides | Sci Rep | 2020
Evidence 5 Activity

Activity

10% Hemolysis
Toxicity
12.8 µM
Hemolytic Cytotoxic
10% Hemolysis | 12.8 | µM | target cell: Dog erythrocytes

Target

Dog erythrocytes

Source & Reference

NA
DBAASP
Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides | Sci Rep | 2020
Evidence 6 Activity

Activity

50% Hemolysis
Toxicity
31.99 µM
Hemolytic Cytotoxic
50% Hemolysis | 31.99 | µM | target cell: Dog erythrocytes

Target

Dog erythrocytes

Source & Reference

NA
DBAASP
Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides | Sci Rep | 2020
Evidence 7 Activity

Activity

100% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
100% Hemolysis | 150 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides | Sci Rep | 2020
Evidence 8 Activity

Activity

10% Hemolysis
Toxicity
20.3 µM
Hemolytic Cytotoxic
10% Hemolysis | 20.3 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides | Sci Rep | 2020
Evidence 9 Activity

Activity

50% Hemolysis
Toxicity
35.1 µM
Hemolytic Cytotoxic
50% Hemolysis | 35.1 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides | Sci Rep | 2020
Evidence 10 Activity

Activity

<8% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
<8% Hemolysis | 150 | µM | target cell: Bovine erythrocytes

Target

Bovine erythrocytes

Source & Reference

NA
DBAASP
Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides | Sci Rep | 2020
Evidence 11 Activity

Activity

10% Hemolysis
Toxicity
>150 µM
Hemolytic Cytotoxic
10% Hemolysis | >150 | µM | target cell: Bovine erythrocytes

Target

Bovine erythrocytes

Source & Reference

NA
DBAASP
Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides | Sci Rep | 2020
Evidence 12 Activity

Activity

50% Hemolysis
Toxicity
>150 µM
Hemolytic Cytotoxic
50% Hemolysis | >150 | µM | target cell: Bovine erythrocytes

Target

Bovine erythrocytes

Source & Reference

NA
DBAASP
Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides | Sci Rep | 2020
Evidence 13 Activity

Activity

50% Cell death
Toxicity
89 µM
Cytotoxic
50% Cell death | 89 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides | Sci Rep | 2020
Evidence 14 Activity

Activity

5% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
5% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activities of twenty lysine-peptoid hybrids against clinically relevant bacteria and fungi | Chemotherapy | 2008
Evidence 15 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Sci Rep. 2020 Aug 6 10(1):13206.