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Peptide record

TPDB27170

Antibacterial Anticancer Antifungal Toxicity modified_plain modified
7 amino acids
Basic Information
3D PDB MODEL
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TPDB27170
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
modified_plain
Yes
A 7-aa modified multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Modified, details unspecified
Sequence
XXXAXLX
Physicochemical Analysis
C9H18N2O3
RNDCEQGHIKMFPSTWYV
AL
202.25
6.02
0
0
2
-0
-0.73
0.800
70.00
Mammalian: Yeast: E.coli:
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C9H18N2O3
202.25
6.02
-0
-0.73
0.800
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
Toxicity
>50 µM
Cytotoxic
IC50 | >50 | µM | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
Rufomycin Targets ClpC1 Proteolysis in Mycobacterium tuberculosis and M. abscessus. | Antimicrob Agents Chemother | 2019
Evidence 2 Activity

Activity

IC50
Toxicity
13 µM
Cytotoxic
IC50 | 13 | µM | target cell: Murine macrophage cells J774A.1

Target

Murine macrophage cells J774A.1

Source & Reference

NA
DBAASP
Rufomycin Targets ClpC1 Proteolysis in Mycobacterium tuberculosis and M. abscessus. | Antimicrob Agents Chemother | 2019
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Agents Chemother. 2019 Feb 26 63(3):e02204-18.