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Peptide record

TPDB27166

Antibacterial Toxicity modified_plain modified
7 amino acids
Basic Information
3D PDB MODEL
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TPDB27166
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 7-aa modified multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
XXWXXXX
Physicochemical Analysis
C11H12N2O2
ARNDCEQGHILKMFPSTYV
W
204.23
6.02
0
0
1
-0
-1.85
-0.129
0.00
Mammalian: Yeast: E.coli:
5500
2693.06
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
7
C11H12N2O2
204.23
6.02
-0
-1.85
-0.129
Evidence Records 6 records
Evidence 1 Activity

Activity

8% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
8% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Delineating the Mechanism of Action of a Protease Resistant and Salt Tolerant Synthetic Antimicrobial Peptide against Pseudomonas aeruginosa. | ACS Omega | 2022
Evidence 2 Activity

Activity

LC50
Toxicity
>300 µM
Cytotoxic
LC50 | >300 | µM | target cell: Human normal embryonic lung cells L132

Target

Human normal embryonic lung cells L132

Source & Reference

NA
DBAASP
Delineating the Mechanism of Action of a Protease Resistant and Salt Tolerant Synthetic Antimicrobial Peptide against Pseudomonas aeruginosa. | ACS Omega | 2022
Evidence 3 Activity

Activity

12.5% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
12.5% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Lysine-homologue substitution: Impact on antimicrobial activity and proteolytic stability of cationic stapled heptapeptides | Bioorg Med Chem | 2024
Evidence 4 Activity

Activity

0.4% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
0.4% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Lysine-homologue substitution: Impact on antimicrobial activity and proteolytic stability of cationic stapled heptapeptides | Bioorg Med Chem | 2024
Evidence 5 Activity

Activity

0.1% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
0.1% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Lysine-homologue substitution: Impact on antimicrobial activity and proteolytic stability of cationic stapled heptapeptides | Bioorg Med Chem | 2024
Evidence 6 Activity

Activity

0.2% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
0.2% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Lysine-homologue substitution: Impact on antimicrobial activity and proteolytic stability of cationic stapled heptapeptides | Bioorg Med Chem | 2024