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Peptide record

TPDB27157

Antibacterial Antifungal Toxicity modified_plain modified
4 amino acids
Basic Information
3D PDB MODEL
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TPDB27157
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
modified_plain
Yes
A 4-aa modified multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Modified, details unspecified
Sequence
XXWW
Physicochemical Analysis
C22H22N4O3
ARNDCEQGHILKMFPSTYV
W
390.44
6.02
0
0
2
-0
-3.70
-0.450
0.00
Mammalian: Yeast: E.coli:
11000
2817.32
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
4
C22H22N4O3
390.44
6.02
-0
-3.70
-0.450
Evidence Records 11 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
455.9 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 455.9 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Non-steroidal anti-inflammatory drugs conjugated ultra-short Peptidomimetics as potent Antibacterials against methicillin resistant S. aureus with anti-inflammatory activity | Bioorg Chem | 2025
Evidence 2 Activity

Activity

12.8% Cytotoxicity
Toxicity
125 µg/mL
Cytotoxic
12.8% Cytotoxicity | 125 | µg/mL | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Non-steroidal anti-inflammatory drugs conjugated ultra-short Peptidomimetics as potent Antibacterials against methicillin resistant S. aureus with anti-inflammatory activity | Bioorg Chem | 2025
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
592.4 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 592.4 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Non-steroidal anti-inflammatory drugs conjugated ultra-short Peptidomimetics as potent Antibacterials against methicillin resistant S. aureus with anti-inflammatory activity | Bioorg Chem | 2025
Evidence 4 Activity

Activity

24.97% Cytotoxicity
Toxicity
125 µg/mL
Cytotoxic
24.97% Cytotoxicity | 125 | µg/mL | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Non-steroidal anti-inflammatory drugs conjugated ultra-short Peptidomimetics as potent Antibacterials against methicillin resistant S. aureus with anti-inflammatory activity | Bioorg Chem | 2025
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
394.4 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 394.4 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Non-steroidal anti-inflammatory drugs conjugated ultra-short Peptidomimetics as potent Antibacterials against methicillin resistant S. aureus with anti-inflammatory activity | Bioorg Chem | 2025
Evidence 6 Activity

Activity

14.3% Cytotoxicity
Toxicity
125 µg/mL
Cytotoxic
14.3% Cytotoxicity | 125 | µg/mL | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Non-steroidal anti-inflammatory drugs conjugated ultra-short Peptidomimetics as potent Antibacterials against methicillin resistant S. aureus with anti-inflammatory activity | Bioorg Chem | 2025
Evidence 7 Activity

Activity

50% Hemolysis
Toxicity
237.9 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 237.9 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Non-steroidal anti-inflammatory drugs conjugated ultra-short Peptidomimetics as potent Antibacterials against methicillin resistant S. aureus with anti-inflammatory activity | Bioorg Chem | 2025
Evidence 8 Activity

Activity

50% Hemolysis
Toxicity
321.1 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 321.1 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Non-steroidal anti-inflammatory drugs conjugated ultra-short Peptidomimetics as potent Antibacterials against methicillin resistant S. aureus with anti-inflammatory activity | Bioorg Chem | 2025
Evidence 9 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of rationally designed amino terminal modified peptides. | Bioorg Med Chem Lett | 2007
Evidence 10 Activity

Activity

10% Hemolysis
Toxicity
10 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 10 | µg/mL | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of short, synthetic cationic lipopeptides. | Chem Biol Drug Des | 2010
Evidence 11 Activity

Activity

Toxicity
Hemolytic
NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of rationally designed amino terminal modified peptides. | Bioorg Med Chem Lett | 2007